Chan Y F, Choi A C, Ma L, Leung M P
Pathology. 1986 Oct;18(4):463-8. doi: 10.3109/00313028609087570.
A case of infantile hemangioendothelioma of the liver presenting with congestive heart failure and massive hepatomegaly in a two-mth old baby is described. Serum alpha-fetoprotein was elevated in this patient and clinically the lesion might not be distinguishable from other, commoner hepatic tumours in children. Histologically the tumour showed a type II pattern as defined by Dehner. The significance of classifying this tumour into two histologic types is discussed. Only 3 cases reported in the English literature were studied by electron microscopy; two of them were type I while the other was a type II lesion. In our case the endothelial cells appeared ultrastructurally less differentiated and architecturally more disorganized than in type I lesions. Like the previous case, the basal lamina showed marked thickening and reduplication. The significance of these findings is discussed.
本文描述了一例两个月大婴儿的肝婴儿血管内皮瘤，该患儿表现为充血性心力衰竭和肝脏巨大肿大。该患者血清甲胎蛋白升高，临床上该病变可能与儿童其他较常见的肝肿瘤难以区分。组织学上，肿瘤表现为德纳尔（Dehner）定义的II型模式。讨论了将该肿瘤分为两种组织学类型的意义。英文文献中仅报道了3例经电子显微镜研究的病例；其中两例为I型，另一例为II型病变。在我们的病例中，内皮细胞在超微结构上比I型病变的细胞分化程度更低，结构更紊乱。与之前的病例一样，基底膜显示出明显增厚和重复。讨论了这些发现的意义。
