Checkoway H, DiFerdinando G, Hulka B S, Mickey D D
Prostate. 1987;10(1):79-88. doi: 10.1002/pros.2990100111.
Information on suspected risk factors for prostate cancer was obtained from in-person interviews as part of a case-control study of tissue sex hormone receptors and serum hormone levels. The risk factors examined were medical history (including venereal disease), sexual history, smoking, alcohol consumption, and occupational exposures. Study subjects were 40 prostate cancer patients and 64 benign prostatic hyperplasia controls who were newly diagnosed during 1984-1985 at North Carolina Memorial Hospital in Chapel Hill. Subjects were white and black men aged 50 years and older. Comparisons of cases' and controls' past medical histories did not support a venereal disease hypothesis of prostate cancer etiology. The most prominent finding is an association with farming employment: 75% of cases compared to 38% of controls reported farmwork occupations. Exposures to pesticides and herbicides, while more common among the patients, did not account for the association detected for farming. No relationship was observed with cadmium exposure, the most frequently cited occupational risk factor for prostate cancer.
作为一项关于组织性激素受体和血清激素水平的病例对照研究的一部分，有关前列腺癌疑似风险因素的信息是通过面对面访谈获取的。所考察的风险因素包括病史（包括性病）、性史、吸烟、饮酒和职业暴露。研究对象为1984年至1985年期间在教堂山的北卡罗来纳大学纪念医院新确诊的40例前列腺癌患者和64例良性前列腺增生对照者。研究对象为年龄在50岁及以上的白人和黑人男性。病例组和对照组既往病史的比较并不支持前列腺癌病因的性病假说。最显著的发现是与从事农业工作有关：75%的病例报告从事农业工作，而对照组这一比例为38%。虽然患者接触杀虫剂和除草剂的情况更为常见，但这并不能解释所检测到的与从事农业工作之间的关联。未观察到与镉暴露之间的关系，镉暴露是前列腺癌最常被提及的职业风险因素。
