Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
Asian J Androl. 2010 Mar;12(2):215-20. doi: 10.1038/aja.2009.86. Epub 2009 Dec 28.
Prostatic calculi are common and are associated with inflammation of the prostate. Recently, it has been suggested that this inflammation may be associated with prostate carcinogenesis. The aim of this study was to investigate the relationship between prostatic calculi and prostate cancer (PCa) in prostate biopsy specimens. We retrospectively analyzed 417 consecutive patients who underwent transrectal ultrasonography (TRUS) and prostate biopsies between January 2005 and January 2008. Based on the biopsy findings, patients were divided into benign prostatic hyperplasia and PCa groups. TRUS was used to detect prostatic calculi and to measure prostate volume. The correlations between PCa risk and age, serum total PSA levels, prostate volume, and prostatic calculi were analyzed. Patient age and PSA, as well as the frequency of prostatic calculi in the biopsy specimens, differed significantly between both the groups (P < 0.05). In the PCa group, the Gleason scores (GSs) were higher in patients with prostatic calculi than in patients without prostatic calculi (P = 0.023). Using multivariate logistic regression analysis, we found that patient age, serum total PSA and prostate volume were risk factors for PCa (P = 0.001), but that the presence of prostatic calculi was not associated with an increased risk of PCa (P = 0.13). In conclusion, although the presence of prostatic calculi was not shown to be a risk factor for PCa, prostatic calculi were more common in patients with PCa and were associated with a higher GS among these men.
前列腺结石很常见，且常伴有前列腺炎症。最近有研究提示这种炎症可能与前列腺癌的发生有关。本研究旨在探讨前列腺结石与前列腺活检组织中前列腺癌（PCa）的关系。我们回顾性分析了 2005 年 1 月至 2008 年 1 月间行经直肠超声（TRUS）和前列腺活检的 417 例连续患者。根据活检结果，患者分为良性前列腺增生和 PCa 组。TRUS 用于检测前列腺结石和测量前列腺体积。分析 PCa 风险与年龄、血清总 PSA 水平、前列腺体积和前列腺结石之间的相关性。两组间患者年龄、PSA 以及活检标本中前列腺结石的频率差异均有统计学意义（P<0.05）。在 PCa 组中，有前列腺结石的患者的 Gleason 评分（GS）高于无前列腺结石的患者（P=0.023）。采用多变量 logistic 回归分析，我们发现患者年龄、血清总 PSA 和前列腺体积是 PCa 的危险因素（P=0.001），但前列腺结石的存在与 PCa 风险增加无关（P=0.13）。总之，尽管前列腺结石的存在不是 PCa 的危险因素，但在 PCa 患者中更常见，且与这些患者的较高 GS 相关。
