Fritschi L, Glass D C, Tabrizi J S, Leavy J E, Ambrosini G L
Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Perth, Western Australia, Australia.
Occup Environ Med. 2007 Jan;64(1):60-5. doi: 10.1136/oem.2006.027706. Epub 2006 Oct 3.
To assess the association of selected occupational exposures with risk of prostate cancer and with risk of benign prostatic hyperplasia (BPH).
This population-based case-control study recruited 606 men with a diagnosis of confirmed prostate cancer, 400 men who had undergone their first prostatectomy for BPH and 471 male controls randomly selected from the electoral roll between 1 August 2001 and 1 October 2002 in Western Australia. chi(2) tests and logistic regressions were used for univariate and multivariate analyses to investigate the association of the two outcomes with occupational exposure to pesticides, fertilisers, metals, wood dust, oils, diesel exhaust and polyaromatic hydrocarbons (PAHs).
Exposure to toxic metals at a non-substantial level increased the risk of BPH (odds ratio (OR) 1.39, 95% confidence interval (CI) 1.1 to 1.84) and led to a non-significant excess risk of prostate cancer (OR 1.25, 95% CI 0.96 to 1.61). Non-significant excess risks were observed for prostate cancer after exposure to oils other than mineral oil (OR 1.54, 95% CI 0.95 to 2.51) and for BPH after exposure to PAHs (OR 1.20, 95% CI 0.91 to 1.58). A non-statistically significant protective effect for prostate cancer was seen after exposure to organophosphate pesticides (OR 0. 69, 95% CI 0.43 to 1.12). No other associations were found for either prostate cancer or BPH and no dose-response relationships were seen for the exposures investigated.
These results do not provide evidence that any of the occupational factors examined are risk factors for either prostate cancer or BPH.
评估特定职业暴露与前列腺癌风险以及良性前列腺增生（BPH）风险之间的关联。
这项基于人群的病例对照研究招募了606名确诊为前列腺癌的男性、400名因BPH首次接受前列腺切除术的男性以及471名于2001年8月1日至2002年10月1日在西澳大利亚从选民名单中随机选取的男性对照。采用卡方检验和逻辑回归进行单因素和多因素分析，以研究这两种结局与职业性接触农药、化肥、金属、木屑、油类、柴油废气和多环芳烃（PAHs）之间的关联。
非大量接触有毒金属会增加BPH风险（优势比（OR）为1.39，95%置信区间（CI）为1.1至1.84），并导致前列腺癌风险有非显著性的增加（OR为1.25，95%CI为0.96至1.61）。接触除矿物油以外的其他油类后前列腺癌有非显著性的风险增加（OR为1.54，95%CI为0.95至2.51），接触PAHs后BPH有非显著性的风险增加（OR为1.20，95%CI为0.91至1.58）。接触有机磷农药后对前列腺癌有非统计学显著性的保护作用（OR为0.69，95%CI为0.43至1.12）。未发现前列腺癌或BPH与其他因素有其他关联，且所研究的暴露因素均未呈现剂量反应关系。
这些结果并未提供证据表明所研究的任何职业因素是前列腺癌或BPH的风险因素。
