Postgraduate Course of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil ; Hospital das Clínicas, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil ; Fundação Hospitalar do Estado de Minas Gerais, 30150 260 Belo Horizonte, MG, Brazil.
Postgraduate Course of Infectious Diseases and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil ; Hospital das Clínicas, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil.
Biomed Res Int. 2013;2013:849504. doi: 10.1155/2013/849504. Epub 2013 Nov 24.
Chagas' disease (ChD), caused by the protozoa Trypanosoma cruzi (T. cruzi), was discovered and described by the Brazilian physician Carlos Chagas in 1909. After a century of original description, trypanosomiasis still brings much misery to humanity and is classified as a neglected tropical disease prevalent in underdeveloped countries, particularly in South America. It is an increasing worldwide problem due to the number of cases in endemic areas and the migration of infected subjects to more developed regions, mainly North America and Europe. Despite its importance, chronic chagas cardiomyopathy (CCC) pathophysiology is yet poorly understood, and independently of its social, clinical, and epidemiological importance, the therapeutic approach of CCC is still transposed from the knowledge acquired from other cardiomyopathies. Therefore, the objective of this review is to describe the treatment of Chagas cardiomyopathy with emphasis on its peculiarities.
恰加斯病（ChD）由原生动物克氏锥虫（T. cruzi）引起，于 1909 年由巴西医生卡洛斯·查加斯（Carlos Chagas）发现并描述。在经历了一个世纪的原始描述后，锥虫病仍然给人类带来了巨大的痛苦，并被归类为在欠发达国家流行的被忽视的热带病，特别是在南美洲。由于流行地区的病例数量以及受感染的患者向更发达地区（主要是北美和欧洲）的迁移，该病已成为一个日益严重的全球问题。尽管恰加斯病很重要，但慢性恰加斯心肌病（CCC）的病理生理学仍未得到很好的理解，并且无论其社会、临床和流行病学的重要性如何，CCC 的治疗方法仍然是从其他心肌病获得的知识转化而来。因此，本综述的目的是描述恰加斯心肌病的治疗方法，并重点介绍其特点。
