Clinical and Experimental Medicine Department, Federico II University of Naples, Naples, Italy.
General and Endoscopic Surgery Unit, San Giovanni Bosco Hospital, Naples, Italy.
Surg Obes Relat Dis. 2014 Mar-Apr;10(2):250-5. doi: 10.1016/j.soard.2013.09.006. Epub 2013 Sep 20.
Obesity is an independent risk factor for gastroesophageal reflux disease (GERD), which is often associated with the presence of a hiatal hernia (HH). Despite increasing popularity of laparoscopic sleeve gastrectomy (LSG) in bariatric surgery, its effect on GERD is still unclear. The objective of this study was to evaluate the effect of LSG with or without hiatal hernia repair (HHR) on GERD in obese patients.
Seventy-eight patients with HH underwent LSG with concomitant HHR (LSG+HHR group). Their data were compared with that of 102 patients without HH, who underwent only LSG (LSG-group). All patients underwent a standardized questionnaire, a double-contrast barium swallow, and an upper-gastrointestinal endoscopy before the surgical procedure and at least 6 months later.
At baseline, the prevalence of GERD symptoms and their frequency-intensity scores did not differ between groups. At follow up, there was a significant decrease in the prevalence of typical GERD symptoms only in the LSG-group (P = .003). LSG+HHR patients showed a significantly higher heartburn frequency-intensity score compared with LSG patients (P = .009).
This finding confirms that LSG has a beneficial effect on relieving GERD symptoms, although the underlying mechanisms are still unclear; conversely, the procedure of HHR did not produce any improvement in GERD symptoms.
肥胖是胃食管反流病(GERD)的一个独立危险因素,而 GERD 常伴有食管裂孔疝(HH)。尽管腹腔镜袖状胃切除术(LSG)在减重手术中越来越受欢迎,但它对 GERD 的影响仍不清楚。本研究旨在评估 LSG 联合或不联合 HH 修补术(HHR)对肥胖患者 GERD 的影响。
78 例 HH 患者行 LSG 联合 HHR(LSG+HHR 组),并与仅行 LSG(LSG 组)的 102 例无 HH 患者进行比较。所有患者在手术前和至少 6 个月后均接受标准化问卷调查、双重对比钡餐和上消化道内镜检查。
基线时,两组 GERD 症状的发生率及其频率-强度评分无差异。随访时,仅 LSG 组 GERD 典型症状的发生率显著下降(P =.003)。LSG+HHR 患者的烧心频率-强度评分明显高于 LSG 患者(P =.009)。
这一发现证实,LSG 对缓解 GERD 症状有有益作用,尽管其潜在机制尚不清楚;相反,HHR 手术并未改善 GERD 症状。