日本痤疮患者面部皮肤常驻微生物群分析。
Analysis of facial skin-resident microbiota in Japanese acne patients.
作者信息
Numata Shigeki, Akamatsu Hirohiko, Akaza Narifumi, Yagami Akiko, Nakata Satoru, Matsunaga Kayoko
机构信息
Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
出版信息
Dermatology. 2014;228(1):86-92. doi: 10.1159/000356777. Epub 2013 Dec 20.
OBJECTIVES
We investigated the facial skin microbiota of Japanese acne patients.
METHODS
Skin swab samples were obtained from 100 acne patients and 28 healthy controls to evaluate Propionibacterium and Staphylococcus spp. using a culture method. Malassezia spp. were evaluated using a nonculture method. Antibiotic resistance of Propionibacterium spp. was also examined.
RESULTS
Acne patients and controls did not show significant differences in Propionibacterium and Staphylococcus spp. populations. However, the number of Malassezia globosa from patients was greater than that from controls. Moreover, the number of Propionibacterium spp. from patients carrying antibiotic-resistant strains was significantly greater than that from patients not carrying them.
CONCLUSIONS
The present study characterized the facial skin microbiota of Japanese acne patients, suggesting a correlation between acne and quantitative differences in Malassezia microbiota. It was also found that the antibiotic resistance of Propionibacterium spp. may affect its abundance in the skin.
目的
我们对日本痤疮患者的面部皮肤微生物群进行了调查。
方法
从100名痤疮患者和28名健康对照者身上采集皮肤拭子样本，采用培养法评估丙酸杆菌和葡萄球菌属。马拉色菌属采用非培养法进行评估。还检测了丙酸杆菌属的抗生素耐药性。
结果
痤疮患者和对照者在丙酸杆菌和葡萄球菌属数量上没有显著差异。然而，患者的球形马拉色菌数量多于对照者。此外，携带抗生素耐药菌株的患者的丙酸杆菌属数量显著多于未携带耐药菌株的患者。
结论
本研究对日本痤疮患者的面部皮肤微生物群进行了特征分析，提示痤疮与马拉色菌微生物群的数量差异之间存在相关性。还发现丙酸杆菌属的抗生素耐药性可能影响其在皮肤中的丰度。
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