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表达假定的第二种T细胞受体γ基因产物的急性白血病

Acute leukemia expressing the gamma gene product of the putative second T cell receptor.

作者信息

González-Sarmiento R, LeBien T W, Bradley J G, Greenberg J M, Seidman J G, Ang S, Kersey J H

出版信息

J Clin Invest. 1987 Apr;79(4):1281-4. doi: 10.1172/JCI112949.

DOI:10.1172/JCI112949
PMID:2435758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424333/
Abstract

Early thymus-derived lymphocytes bearing the T gamma gene product in association with the CD3(T3) complex have recently been described. We report a unique case of human acute lymphoblastic leukemia with a CD2+, CD3+, CD4-, CD5+, CD7+, CD8-, WT31- phenotype. These cells were found to have T gamma gene rearrangement and T gamma transcripts in absence of T alpha or T beta rearrangement or transcripts. Immunoprecipitation studies with anti-CD3 antibodies showed a 43-kD protein associated with T3; this 43-kD protein is also precipitated with antiserum raised against synthetic peptides representing the constant region of the putative T gamma protein.

摘要

最近已描述了早期胸腺来源的淋巴细胞带有与CD3（T3）复合物相关的Tγ基因产物。我们报告了1例具有CD2 +、CD3 +、CD4 -、CD5 +、CD7 +、CD8 -、WT31 - 表型的人类急性淋巴细胞白血病的独特病例。发现这些细胞有Tγ基因重排和Tγ转录本，而不存在Tα或Tβ重排或转录本。用抗CD3抗体进行的免疫沉淀研究显示有一种与T3相关的43-kD蛋白；这种43-kD蛋白也能用针对代表推定的Tγ蛋白恒定区的合成肽产生的抗血清沉淀出来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2666/424333/bac6c2868589/jcinvest00115-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2666/424333/230e1ecb544f/jcinvest00115-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2666/424333/337029ea0df6/jcinvest00115-0270-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2666/424333/5f1af313474f/jcinvest00115-0270-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2666/424333/bac6c2868589/jcinvest00115-0271-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2666/424333/230e1ecb544f/jcinvest00115-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2666/424333/337029ea0df6/jcinvest00115-0270-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2666/424333/5f1af313474f/jcinvest00115-0270-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2666/424333/bac6c2868589/jcinvest00115-0271-a.jpg

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1
Acute leukemia expressing the gamma gene product of the putative second T cell receptor.表达假定的第二种T细胞受体γ基因产物的急性白血病
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[Phenotypic analysis of immature T-lineage cells].[未成熟T细胞系细胞的表型分析]
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引用本文的文献

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2
Expression of T cell receptor delta chains in benign and malignant T lineage lymphoproliferations.T细胞受体δ链在良性和恶性T系淋巴细胞增殖中的表达
Am J Pathol. 1988 Sep;132(3):401-5.
3
T-cell acute childhood lymphoblastic leukemia with chromosome 14 q 11 anomaly: a morphologic, immunologic, and cytogenetic analysis of 10 patients.

本文引用的文献

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Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage.人类胸腺内分化的离散阶段：T细胞系正常胸腺细胞和白血病淋巴母细胞的分析
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伴有14号染色体q11异常的儿童T细胞急性淋巴细胞白血病：10例患者的形态学、免疫学及细胞遗传学分析
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小鼠和人类T细胞上主要组织相容性复合体限制的抗原受体：恒定和可变肽段的鉴定
Cell. 1983 Nov;35(1):295-302. doi: 10.1016/0092-8674(83)90232-5.
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The human T-cell receptor.人类T细胞受体。
Annu Rev Immunol. 1984;2:23-50. doi: 10.1146/annurev.iy.02.040184.000323.
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6
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.一个人类T细胞特异性cDNA克隆编码一种与免疫球蛋白链具有广泛同源性的蛋白质。
Nature. 1984;308(5955):145-9. doi: 10.1038/308145a0.
7
Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences.从cDNA序列推导的异源二聚体T细胞受体的完整一级结构
Nature. 1984;309(5971):757-62. doi: 10.1038/309757a0.
8
The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins.人类T淋巴细胞上的T3复合物由四种结构不同的糖蛋白组成。
J Biol Chem. 1983 Apr 25;258(8):5135-41.
9
Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man.区分小鼠和人类T淋巴细胞辅助/诱导亚群与细胞毒性/抑制亚群的表面分子的进化保守性。
J Exp Med. 1981 Feb 1;153(2):310-23. doi: 10.1084/jem.153.2.310.
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Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.克隆t(14;18) 人类淋巴瘤的染色体断点：聚集在14号染色体上的JH周围以及18号染色体上一个转录单位附近。
Cell. 1985 Jul;41(3):899-906. doi: 10.1016/s0092-8674(85)80070-2.