International Livestock Research Institute, Old Naivasha Road, PO Box 30709, 00100 Nairobi, Kenya.
Vet Res. 2013 Dec 20;44(1):122. doi: 10.1186/1297-9716-44-122.
Contagious bovine pleuropneumonia (CBPP) caused by Mycoplasma mycoides subsp. mycoides (Mmm) is an economically very important cattle disease in sub-Saharan Africa. CBPP impacts animal health and poverty of livestock-dependent people through decreased animal productivity, reduced food supply, and the cost of control measures. CBPP is a barrier to trade in many African countries and this reduces the value of livestock and the income of many value chain stakeholders. The presence of CBPP also poses a constant threat to CBPP-free countries and creates costs in terms of the measures necessary to ensure the exclusion of disease. This opinion focuses on the biomedical research needed to foster the development of better control measures for CBPP. We suggest that different vaccine development approaches are followed in parallel. Basic immunology studies and systematic OMICs studies will be necessary in order to identify the protective arms of immunity and to shed more light on the pathogenicity mechanisms in CBPP. Moreover a robust challenge model and a close collaboration with African research units will be crucial to foster and implement a new vaccine for the progressive control of this cattle plague.
传染性牛胸膜肺炎（CBPP）由牛支原体亚种（Mmm）引起，是撒哈拉以南非洲地区一种对牛具有重要经济意义的疾病。通过降低动物生产力、减少食物供应以及控制措施的成本，CBPP 影响动物健康和依赖牲畜的人们的贫困状况。在许多非洲国家，CBPP 是贸易的障碍，这降低了牲畜的价值和许多价值链利益相关者的收入。CBPP 的存在也对无 CBPP 国家构成持续威胁，并需要采取措施来确保排除疾病，这会产生成本。本意见重点关注促进制定更好的 CBPP 控制措施所需的生物医学研究。我们建议同时采用不同的疫苗开发方法。为了确定保护性免疫的作用以及更深入地了解 CBPP 的发病机制，有必要进行基础免疫学研究和系统的 OMICS 研究。此外，建立强大的挑战模型并与非洲研究单位密切合作，对于促进和实施新疫苗以逐步控制这种牛瘟至关重要。
