Rosa Vinicius
National University of Singapore, Oral Sciences, Faculty of Dentistry, 11 Lower Kent Ridge Road, Singapore 119083, Singapore.
Singapore Dent J. 2013 Dec;34(1):13-8. doi: 10.1016/j.sdj.2013.11.003.
Disinfection of root canals followed by the replacement of the infected or inflamed pulp tissues by inert materials is the foundation for treating irreversible damaged dental pulps. The management of pathological conditions of the periodontium is mainly based solely upon infection control via the reestablishment of oral hygiene, scaling and root planing to control inflammation which stops progressive bone loss. As one may see, the clinical management of endodontic and periodontal diseases has not changed drastically despite the development of new materials, techniques and medicaments. Tissue engineering is a multi-disciplinary field focused on the development of materials, techniques and strategies to improve or replace damaged or lost biological functions and tissues. As the tissue engineering field progresses, "scaffolds", "suggest pathways" and "stem cells" abandoned their role as technical words exclusively used by scientists and slowly assume a part in the language of students, educators, clinicians and patients. However the unfamiliarity with some of the concepts can lead to misinterpretations of the current status and overexcitement about future applications of stem cells for dental-related tissue regeneration. This paper will present a panorama and the future challenges on the path to use of stem cells for endodontic and periodontal tissue regeneration.
根管消毒并随后用惰性材料替代感染或发炎的牙髓组织是治疗不可逆性牙髓损伤的基础。牙周组织病理状况的处理主要仅基于通过重建口腔卫生、龈上洁治和根面平整来控制感染，以控制炎症并阻止骨质进一步丧失。可以看出，尽管有新材料、新技术和新药物的发展，但牙髓病和牙周病的临床治疗方法并没有发生巨大变化。组织工程是一个多学科领域，专注于开发材料、技术和策略，以改善或替代受损或丧失的生物功能及组织。随着组织工程领域的发展，“支架”“信号通路”和“干细胞”不再仅仅是科学家专用的技术术语，而是逐渐在学生、教育工作者、临床医生和患者的语言中占据一席之地。然而，对某些概念的不熟悉可能导致对干细胞当前状况的误解以及对其在牙科相关组织再生未来应用的过度兴奋。本文将概述干细胞用于牙髓和牙周组织再生的现状及未来挑战。
