Klinika of Stomatology and Maxillofacial Surgery Akadémia Košice Bacikova, Pavol Jozef Šafárik University, 040 01 Kosice, Slovakia.
Lyles School of Civil Engineering, Purdue University, West Lafayette, IN 47907, USA.
Cells. 2024 Jun 19;13(12):1065. doi: 10.3390/cells13121065.
Bone tissue injuries within oral and dental contexts often present considerable challenges because traditional treatments may not be able to fully restore lost or damaged bone tissue. Novel approaches involving stem cells and targeted 3D scaffolds have been investigated in the search for workable solutions. The use of scaffolds in stem cell-assisted bone regeneration is a crucial component of tissue engineering techniques designed to overcome the drawbacks of traditional bone grafts. This study provides a detailed review of scaffold applications for bone regeneration with stem cells in dentistry. This review focuses on scaffolds and stem cells while covering a broad range of studies explaining bone regeneration in dentistry through the presentation of studies conducted in this field. The role of different stem cells in regenerative medicine is covered in great detail in the reviewed literature. These studies have addressed a wide range of subjects, including the effects of platelet concentrates during dental surgery or specific combinations, such as human dental pulp stem cells with scaffolds for animal model bone regeneration, to promote bone regeneration in animal models. Noting developments, research works consider methods to improve vascularization and explore the use of 3D-printed scaffolds, secretome applications, mesenchymal stem cells, and biomaterials for oral bone tissue regeneration. This thorough assessment outlines possible developments within these crucial regenerative dentistry cycles and provides insights and suggestions for additional study. Furthermore, alternative creative methods for regenerating bone tissue include biophysical stimuli, mechanical stimulation, magnetic field therapy, laser therapy, nutritional supplements and diet, gene therapy, and biomimetic materials. These innovative approaches offer promising avenues for future research and development in the field of bone tissue regeneration in dentistry.
口腔和牙科领域的骨组织损伤常常带来很大的挑战，因为传统的治疗方法可能无法完全恢复丢失或受损的骨组织。在寻找可行的解决方案的过程中，涉及干细胞和靶向 3D 支架的新方法已经得到了研究。在干细胞辅助骨再生中使用支架是组织工程技术的一个关键组成部分，旨在克服传统骨移植物的缺点。本研究对牙科中使用支架和干细胞进行骨再生的应用进行了详细的综述。本综述侧重于支架和干细胞，同时涵盖了广泛的研究，通过介绍该领域的研究来解释牙科中的骨再生。在综述文献中详细介绍了不同干细胞在再生医学中的作用。这些研究涉及了广泛的主题，包括在牙科手术中血小板浓缩物的作用或特定组合，例如与人牙髓干细胞与支架结合用于动物模型骨再生，以促进动物模型中的骨再生。注意到发展，研究工作考虑了改善血管化的方法，并探索了使用 3D 打印支架、分泌组应用、间充质干细胞和生物材料进行口腔骨组织再生的方法。本全面评估概述了这些关键再生牙科周期内的可能发展，并为进一步研究提供了见解和建议。此外，用于骨组织再生的替代创新方法包括生物物理刺激、机械刺激、磁场疗法、激光疗法、营养补充剂和饮食、基因疗法和仿生材料。这些创新方法为牙科领域骨组织再生的未来研究和发展提供了有前途的途径。
