Gohel Mukesh G, Chacko Anusha N
Department of Biochemistry, B. J. Medical College & Civil Hospital, Ahmedabad, India.
Department of Biochemistry, GDERS Dental College, Siddhapur, India.
J Diabetes Metab Disord. 2013 Dec 20;12(1):56. doi: 10.1186/2251-6581-12-56.
Diabetes is undoubtedly one of the most challenging health problems in 21st century. Understanding the pathogenesis and preventing long term complications have been major goals of research in diabetes mellitus (DM). Research in the past few years has linked oxidative stress and inflammation to beta cell dysfunction. Aim of this study is to evaluate serum gamma-glutamyl transferase (GGT) activity (marker of oxidative stress) and high sensitivity C reactive protein (hsCRP) level (an inflammatory marker) in type 2 DM subjects with good and poor glycemic control. Further, we investigated correlation between serum GGT and hsCRP level with glycemic control (FBS, PP2BS, HbA1c) in subjects.
A cross sectional study consists of 150 patients out of them 50 patients having type 2 DM with good control (Group II), 50 patients with type 2 DM with poor control (Group III) and 50 normal healthy control (Group I) were selected. Serum GGT, serum hsCRP, FBS, PP2BS, HbA1c, and other biochemical investigations include serum liver enzymes and lipids were measured.
Mean serum GGT and hsCRP concentration were statistically significantly higher in group III patients compared to group I and group II subjects as well as increased in group II compared to group I (p < 0.001). Further significant positive correlation was observed between GGT and hsCRP concentration as well as both with HbA1c, FBS, and PP2BS.
Oxidative stress and inflammation appears to be a key component and also associated with poor glycemic control and further pathogenesis of diabetes and its complications. All our finding suggesting a link between oxidative stress, inflammation and glycemic control in patient with type 2 diabetes mellitus.
糖尿病无疑是21世纪最具挑战性的健康问题之一。了解其发病机制并预防长期并发症一直是糖尿病研究的主要目标。过去几年的研究已将氧化应激和炎症与β细胞功能障碍联系起来。本研究的目的是评估血糖控制良好和较差的2型糖尿病患者的血清γ-谷氨酰转移酶（GGT）活性（氧化应激标志物）和高敏C反应蛋白（hsCRP）水平（炎症标志物）。此外，我们还研究了受试者血清GGT和hsCRP水平与血糖控制（空腹血糖、餐后2小时血糖、糖化血红蛋白）之间的相关性。
一项横断面研究选取了150例患者，其中50例血糖控制良好的2型糖尿病患者（第二组），50例血糖控制较差的2型糖尿病患者（第三组），以及50例正常健康对照者（第一组）。检测血清GGT、血清hsCRP、空腹血糖、餐后2小时血糖、糖化血红蛋白，以及其他生化指标，包括血清肝酶和血脂。
与第一组和第二组受试者相比，第三组患者的血清GGT和hsCRP平均浓度在统计学上显著更高，且第二组相比于第一组也有所升高（p < 0.001）。此外，GGT和hsCRP浓度之间以及二者与糖化血红蛋白、空腹血糖和餐后2小时血糖之间均观察到显著的正相关。
氧化应激和炎症似乎是一个关键因素，并且还与血糖控制不佳以及糖尿病及其并发症的进一步发病机制相关。我们所有的发现表明2型糖尿病患者的氧化应激、炎症与血糖控制之间存在联系。
