人类c-yes基因cDNA克隆的特性分析
Characterization of cDNA clones for the human c-yes gene.
作者信息
Sukegawa J, Semba K, Yamanashi Y, Nishizawa M, Miyajima N, Yamamoto T, Toyoshima K
出版信息
Mol Cell Biol. 1987 Jan;7(1):41-7. doi: 10.1128/mcb.7.1.41-47.1987.
Abstract
Three c-yes cDNA clones were obtained from poly(A)+ RNA of human embryo fibroblasts. Sequence analysis of the clones showed that they contained inserts corresponding to nearly full-length human c-yes mRNA, which could encode a polypeptide of 543 amino acids with a relative molecular weight (Mr) of 60,801. The predicted amino acid sequence of the protein has no apparent membrane-spanning region or suspected ligand binding domain and closely resembles pp60c-src. Comparison of the sequences of c-yes and v-yes revealed that the v-yes gene contains most of the c-yes coding sequence except the region encoding its extreme carboxyl terminus. The region missing from the v-yes protein is the part that is highly conserved in cellular gene products of the protein-tyrosine kinase family.
摘要
从人胚胎成纤维细胞的聚腺苷酸加尾RNA中获得了三个c-yes cDNA克隆。对这些克隆的序列分析表明，它们包含对应于几乎全长人c-yes mRNA的插入片段，该mRNA可编码一个由543个氨基酸组成、相对分子质量（Mr）为60,801的多肽。该蛋白质的预测氨基酸序列没有明显的跨膜区域或可疑的配体结合结构域，并且与pp60c-src非常相似。c-yes和v-yes序列的比较显示，v-yes基因包含c-yes的大部分编码序列，但不包括编码其极端羧基末端的区域。v-yes蛋白缺失的区域是在蛋白质酪氨酸激酶家族的细胞基因产物中高度保守的部分。
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