GENSAT BAC cre-recombinase 驱动线可用于研究大脑皮层和基底神经节回路的功能组织。
GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits.
机构信息
Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA.
Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA.
出版信息
Neuron. 2013 Dec 18;80(6):1368-83. doi: 10.1016/j.neuron.2013.10.016.
Abstract
Recent development of molecular genetic techniques are rapidly advancing understanding of the functional role of brain circuits in behavior. Critical to this approach is the ability to target specific neuron populations and circuits. The collection of over 250 BAC Cre-recombinase driver lines produced by the GENSAT project provides a resource for such studies. Here we provide characterization of GENSAT BAC-Cre driver lines with expression in specific neuroanatomical pathways within the cerebral cortex and basal ganglia.
摘要
最近分子遗传学技术的发展迅速推进了我们对大脑回路在行为中的功能作用的理解。这种方法的关键是能够针对特定的神经元群体和回路。GENSAT 项目产生的超过 250 个 BAC Cre 重组酶驱动线的集合为这类研究提供了资源。在这里，我们对 GENSAT BAC-Cre 驱动线在大脑皮层和基底神经节中的特定神经解剖途径中的表达进行了特征描述。
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