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Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models.帕金森病模型中纹状体苍白球神经元上谷氨酸能突触的选择性消除。
Nat Neurosci. 2006 Feb;9(2):251-9. doi: 10.1038/nn1632. Epub 2006 Jan 15.
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A genetic approach to access serotonin neurons for in vivo and in vitro studies.一种用于体内和体外研究的获取血清素神经元的遗传学方法。
Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16472-7. doi: 10.1073/pnas.0504510102. Epub 2005 Oct 26.
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Ontogeny of tyrosine hydroxylase mRNA expression in mid- and forebrain: neuromeric pattern and novel positive regions.中脑和前脑酪氨酸羟化酶mRNA表达的个体发生：神经节模式和新的阳性区域。
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Targeted gene expression in dopamine and serotonin neurons of the mouse brain.小鼠脑中多巴胺能和5-羟色胺能神经元的靶向基因表达
J Neurosci Methods. 2005 Apr 15;143(1):27-32. doi: 10.1016/j.jneumeth.2004.09.020. Epub 2004 Nov 24.
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Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus.源自酪氨酸羟化酶基因座的Cre重组酶的转基因表达。
Genesis. 2004 Oct;40(2):67-73. doi: 10.1002/gene.20065.
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Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice.谈一场变革：位点特异性重组酶对小鼠遗传分析的影响
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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.基于细菌人工染色体的中枢神经系统基因表达图谱。
Nature. 2003 Oct 30;425(6961):917-25. doi: 10.1038/nature02033.
8
Cerebellar granule cell Cre recombinase expression.小脑颗粒细胞Cre重组酶表达
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Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication.使用含有R6Kγ复制起点的新型穿梭载体对细菌人工染色体（BAC）进行高效修饰。
Genome Res. 2002 Dec;12(12):1992-8. doi: 10.1101/gr.476202.
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Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice.通过在转基因小鼠中Cre介导的小麦胚凝集素诱导对多种中枢神经系统回路进行跨神经元追踪。
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15148-53. doi: 10.1073/pnas.222546999. Epub 2002 Oct 21.

利用细菌人工染色体构建体将Cre重组酶靶向特定神经元群体。

Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs.

作者信息

Gong Shiaoching, Doughty Martin, Harbaugh Carroll R, Cummins Alexander, Hatten Mary E, Heintz Nathaniel, Gerfen Charles R

机构信息

Gene Expression Nervous System Atlas Project, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA.

出版信息

J Neurosci. 2007 Sep 12;27(37):9817-23. doi: 10.1523/JNEUROSCI.2707-07.2007.

DOI:10.1523/JNEUROSCI.2707-07.2007
PMID:17855595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6672645/
Abstract

Transgenic mouse lines are characterized with Cre recombinase driven by promoters of CNS-specific genes using bacterial artificial chromosome (BAC) constructs. BAC-Cre constructs for 10 genes (, , , , , , , , , and ) produced 14 lines with Cre expression in specific neuronal and glial populations in the brain. These Cre driver lines add functional utility to the >500 BAC-EGFP (enhanced green fluorescent protein) transgenic mouse lines that are part of the Gene Expression Nervous System Atlas Project.

摘要

转基因小鼠品系的特征是使用细菌人工染色体（BAC）构建体，由中枢神经系统特异性基因的启动子驱动Cre重组酶。针对10个基因（，，，，，，，，，和）构建的BAC-Cre构建体产生了14个品系，这些品系在大脑中的特定神经元和神经胶质细胞群体中表达Cre。这些Cre驱动品系为作为基因表达神经系统图谱项目一部分的500多个BAC-EGFP（增强型绿色荧光蛋白）转基因小鼠品系增添了功能实用性。