杏仁核损伤对眶额皮质和内侧前额叶皮质中奖赏值编码的影响。
Effects of amygdala lesions on reward-value coding in orbital and medial prefrontal cortex.
机构信息
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, Building 49, Suite 1B80, 49 Convent Drive, Bethesda, MD 20892, USA.
Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, Building 49, Suite 1B80, 49 Convent Drive, Bethesda, MD 20892, USA.
出版信息
Neuron. 2013 Dec 18;80(6):1519-31. doi: 10.1016/j.neuron.2013.09.036.
We examined the contribution of the amygdala to value signals within orbital prefrontal cortex (OFC) and medial prefrontal cortex (MFC). On each trial, monkeys chose between two stimuli that were associated with different quantities of reward. In intact monkeys, as expected, neurons in both OFC and MFC signaled the reward quantity associated with stimuli. Contrasted with MFC, OFC contained a larger proportion of neurons encoding reward quantity and did so with faster response latencies. Removing the amygdala eliminated these differences, mainly by decreasing value coding in OFC. Similar decreases occurred in OFC immediately before and after reward delivery. Although the amygdala projects to both OFC and MFC, we found that it has its greatest influence over reward-value coding in OFC. Notably, amygdala lesions did not abolish value coding in OFC, which shows that OFC's representations of the value of objects, choices, and outcomes depends, in large part, on other sources.
我们研究了杏仁核对眶额皮质（OFC）和内侧前额皮质（MFC）内价值信号的贡献。在每次试验中，猴子在两种与不同数量奖励相关的刺激之间进行选择。在完整的猴子中，正如预期的那样，OFC 和 MFC 中的神经元都发出与刺激相关的奖励数量信号。与 MFC 相比，OFC 包含更大比例的编码奖励数量的神经元，并且响应潜伏期更快。去除杏仁核消除了这些差异，主要是通过减少 OFC 中的价值编码。在奖励传递前后，OFC 中也出现了类似的减少。尽管杏仁核投射到 OFC 和 MFC，但我们发现它对 OFC 中的奖励价值编码有最大的影响。值得注意的是，杏仁核损伤并没有消除 OFC 中的价值编码，这表明 OFC 对物体、选择和结果的价值的表示在很大程度上依赖于其他来源。
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