Furudate Naomichi, Komada Yoko, Kobayashi Mina, Nakajima Shun, Inoue Yuichi
Department of Somnology, Tokyo Medical University, Tokyo, Japan; Department of Psychiatry, Tokyo Medical University, Tokyo, Japan.
Department of Somnology, Tokyo Medical University, Tokyo, Japan; Japan Somnology Center, Neuropsychiatric Research Institute, Tokyo, Japan.
J Neurol Sci. 2014 Jan 15;336(1-2):232-6. doi: 10.1016/j.jns.2013.11.001. Epub 2013 Nov 11.
We investigated daytime dysfunction in children with restless legs syndrome (RLS) and the effects of treatment primarily with iron supplements on RLS symptoms and daytime dysfunction. We recruited 25 children with RLS (male:female=6:19, mean age at study onset: 12.3 years) for this prospective study, assessing their demographics, symptomatic characteristics, serum ferritin levels, and daytime functioning using the ADHD Rating Scale IV (ADHD-RS-IV), the Pediatric Symptom Checklist (PSC), and the Pediatric Quality of Life Inventory (PedsQL™). Children with RLS were compared with 28 controls (male:female=10:18, mean age: 13.2 years) on these measures, pre- and post-treatment. Before treatment, ADHD-RS-IV (all ps<0.05) and PSC scores (p<0.05) were significantly higher and PedsQL™ scores (all ps<0.05) significantly lower in the RLS group than in the control group. Eight and one of the RLS group had abnormally high PSC and ADHD-RS-IV scores, respectively. Following treatment, participants' daytime function had improved to levels similar to those of controls. Sixteen out of twenty-three cases were successfully treated primarily with iron supplement. Some children with RLS have daytime dysfunction; however, this can be treated with iron supplements.
我们调查了不宁腿综合征（RLS）患儿的日间功能障碍，以及主要使用铁补充剂治疗对RLS症状和日间功能障碍的影响。我们招募了25名RLS患儿（男:女 = 6:19，研究开始时的平均年龄：12.3岁）进行这项前瞻性研究，使用注意力缺陷多动障碍评定量表第四版（ADHD-RS-IV）、儿童症状清单（PSC）和儿童生活质量量表（PedsQL™）评估他们的人口统计学特征、症状特点、血清铁蛋白水平和日间功能。在治疗前和治疗后，将RLS患儿与28名对照者（男:女 = 10:18，平均年龄：13.2岁）在这些指标上进行比较。治疗前，RLS组的ADHD-RS-IV评分（所有p值<0.05）和PSC评分（p<0.05）显著更高，而PedsQL™评分（所有p值<0.05）显著更低。RLS组分别有8名和1名患儿的PSC和ADHD-RS-IV评分异常高。治疗后，参与者的日间功能改善到了与对照者相似的水平。23例中有16例主要通过补充铁剂成功治疗。一些RLS患儿存在日间功能障碍；然而，这可以通过补充铁剂进行治疗。
