Yan Han, Fang Min, Liu Xue-Yuan
Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Middle Yanchang Road No. 301, Zhabei District, Shanghai 200072, China.
ScientificWorldJournal. 2013 Dec 2;2013:459692. doi: 10.1155/2013/459692.
microRNAs (miRNA), a sort of noncoding RNAs widely distributed in eukaryotic cells, could regulate gene expression by inhibiting transcription or translation. They were involved in important physiological and pathological processes including growth, development, and occurrence and progression of diseases. miRNAs are crucial for the development of the nervous system. Recent studies have demonstrated that some miRNAs play important roles in the occurrence and development of ischemic cerebrovascular diseases such as stroke and were also involved in the occurrence and development of poststroke depression (PSD). Herein, studies on the role of miRNAs in the cerebral ischemia and PSD were reviewed, and results may be helpful for the diagnosis and prognosis of cerebral ischemia and PSD with miRNAs in clinical practice.
微小RNA(miRNA)是一类广泛分布于真核细胞中的非编码RNA,可通过抑制转录或翻译来调控基因表达。它们参与了包括生长、发育以及疾病的发生和发展等重要的生理和病理过程。miRNA对神经系统的发育至关重要。最近的研究表明,一些miRNA在缺血性脑血管疾病如中风的发生和发展中起重要作用,并且也参与了中风后抑郁症(PSD)的发生和发展。在此,综述了miRNA在脑缺血和PSD中的作用研究,其结果可能有助于在临床实践中利用miRNA对脑缺血和PSD进行诊断和预后评估。