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微小RNA在中风及中风后抑郁中的作用。

Role of microRNAs in stroke and poststroke depression.

作者信息

Yan Han, Fang Min, Liu Xue-Yuan

机构信息

Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Middle Yanchang Road No. 301, Zhabei District, Shanghai 200072, China.

出版信息

ScientificWorldJournal. 2013 Dec 2;2013:459692. doi: 10.1155/2013/459692.

Abstract

microRNAs (miRNA), a sort of noncoding RNAs widely distributed in eukaryotic cells, could regulate gene expression by inhibiting transcription or translation. They were involved in important physiological and pathological processes including growth, development, and occurrence and progression of diseases. miRNAs are crucial for the development of the nervous system. Recent studies have demonstrated that some miRNAs play important roles in the occurrence and development of ischemic cerebrovascular diseases such as stroke and were also involved in the occurrence and development of poststroke depression (PSD). Herein, studies on the role of miRNAs in the cerebral ischemia and PSD were reviewed, and results may be helpful for the diagnosis and prognosis of cerebral ischemia and PSD with miRNAs in clinical practice.

摘要

微小RNA(miRNA)是一类广泛分布于真核细胞中的非编码RNA,可通过抑制转录或翻译来调控基因表达。它们参与了包括生长、发育以及疾病的发生和发展等重要的生理和病理过程。miRNA对神经系统的发育至关重要。最近的研究表明,一些miRNA在缺血性脑血管疾病如中风的发生和发展中起重要作用,并且也参与了中风后抑郁症(PSD)的发生和发展。在此,综述了miRNA在脑缺血和PSD中的作用研究,其结果可能有助于在临床实践中利用miRNA对脑缺血和PSD进行诊断和预后评估。

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本文引用的文献

1
The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine.
Transl Psychiatry. 2013 Aug 13;3(8):e291. doi: 10.1038/tp.2013.65.
2
Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review.
Neurology. 2013 Jul 16;81(3):264-72. doi: 10.1212/WNL.0b013e31829bfde3.
3
Exceptional stories of microRNAs.
Exp Biol Med (Maywood). 2013 Apr;238(4):339-43. doi: 10.1258/ebm.2012.012251.
4
MicroRNAs as effectors of brain function.
Stroke. 2013 Jun;44(6 Suppl 1):S17-9. doi: 10.1161/STROKEAHA.113.000985.
6
MicroRNAs: regulators of neuronal fate.
Curr Opin Cell Biol. 2013 Apr;25(2):215-21. doi: 10.1016/j.ceb.2012.12.007. Epub 2013 Jan 29.
7
miRNAs as modulators of angiogenesis.
Cold Spring Harb Perspect Med. 2013 Feb 1;3(2):a006643. doi: 10.1101/cshperspect.a006643.
8
Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16.
Transl Psychiatry. 2011 Nov 22;1(11):e56. doi: 10.1038/tp.2011.54.
9
MicroRNAs in neuronal function and dysfunction.
Trends Neurosci. 2012 May;35(5):325-34. doi: 10.1016/j.tins.2012.01.004. Epub 2012 Mar 19.
10
Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target.
Brain Struct Funct. 2013 Jan;218(1):59-72. doi: 10.1007/s00429-011-0376-z. Epub 2012 Jan 14.

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