Zilov V G, Patyshakuliev A P, Merkur'eva R V, Ivanova L I, Rogacheva S K
Zh Vyssh Nerv Deiat Im I P Pavlova. 1986 Nov-Dec;36(6):1045-53.
Similar changes in feeding and avoidance reaction in spite of the way of substance P administration (30 mgk/kg intravenously or 14,8 nmol intraventricular) were found in rabbits with electrodes implanted in various limbic-midbrain structures. Feeding was found to be more sensitive to substance P administration, as it was shown by the decrease of excitability of the hypothalamic "feeding center" and abolishing of the inhibitory and facilitatory effects on this center from the dorsal hippocampus and the midbrain reticular formation, correspondingly. New cortical-subcortical integration under substance P was presented in new characteristics of EEG activity in neocortical areas, both background and in response to stimulation of various limbic-midbrain structures. Biochemical data let to suggest that at the neural level substance P led to destabilization of membrane structures in endoplasmatic reticulum and to redistribution of membrane-connected N-acetylneuramine acid which was directly involved in neurotransmission.
在将电极植入不同边缘 - 中脑结构的兔子中，无论采用何种P物质给药方式（静脉注射30mg/kg或脑室内注射14.8nmol），均发现摄食和回避反应有类似变化。结果发现，摄食对P物质给药更为敏感，这表现为下丘脑“摄食中枢”兴奋性降低，以及背侧海马体和中脑网状结构对该中枢的抑制和促进作用相应消失。P物质作用下新的皮质 - 皮质下整合表现为新皮质区域脑电图活动的新特征，包括背景活动以及对各种边缘 - 中脑结构刺激的反应。生化数据表明，在神经水平上，P物质导致内质网中膜结构的不稳定，并导致直接参与神经传递的膜连接N - 乙酰神经氨酸重新分布。
