Bogavac Mirjana, Brkić Snezana, Celić Dejan, Simin Nataja, Matijasević Jovan, Ilić Tatjana
Faculty of Medicine, University of Novi Sad, Serbia.
Department of Chemistry, Faculty of Sciences, Novi Sad, Serbia.
Srp Arh Celok Lek. 2013 Sep-Oct;141(9-10):623-8. doi: 10.2298/sarh1310623b.
Preterm delivery (PTD), defined as a delivery between 24th and 37th completed week, increases the risk of neonatal morbidity and mortality. There is a growing body of evidence that the intrauterine infection as well as cervicovaginal bacterial infections and Chlamydia infections are possible causes of preterm delivery. Host response to cervicovaginal and/or intrauterine infections is coupled with a release of various inflammatory mediators, many of which are cytokines.
The aim of the study was to find out if cervical infection influenced the serum levels of interferon-gamma (IFN-gamma), interleukin 8 (IL-8) and interleukin 10 (IL-10) in patients with the clinical symptoms of the imminent preterm delivery.
A total of 128 pregnant women (from 24 to 30 weeks of gestation) with the clinical symptoms of the imminent preterm delivery were divided in: study group--85 patients with the cervical infection, and control group--43 patients without the cervical infection. The level of cytokines in the serum was measured with commercial ELISA tests.
No significant difference could be found in serum levels of IFN-gamma (p = 0.632), IL-8 (p = 0.712) and IL-10 (p = 0.676) between these two investigated groups.
The results of our study suggest that there is no significant difference in serum IFN-gamma, IL-8 and IL-10 concentrations between pregnant women with the symptoms of the imminent preterm delivery who had and had no cervical infection.
早产（PTD）定义为妊娠满24周至37周之间分娩，会增加新生儿发病和死亡风险。越来越多的证据表明，宫内感染以及宫颈阴道细菌感染和衣原体感染可能是早产的原因。宿主对宫颈阴道和/或宫内感染的反应伴随着各种炎症介质的释放，其中许多是细胞因子。
本研究旨在查明宫颈感染是否会影响有早产临产临床症状患者的血清干扰素-γ（IFN-γ）、白细胞介素8（IL-8）和白细胞介素10（IL-10）水平。
将128例有早产临产临床症状的孕妇（妊娠24至30周）分为：研究组——85例有宫颈感染的患者，对照组——43例无宫颈感染的患者。用商业酶联免疫吸附测定法检测血清中细胞因子的水平。
在这两个研究组之间，血清IFN-γ（p = 0.632）、IL-8（p = 0.712）和IL-10（p = 0.676）水平未发现显著差异。
我们的研究结果表明，有早产临产症状且有或无宫颈感染的孕妇之间，血清IFN-γ、IL-8和IL-10浓度无显著差异。
