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治疗难治性前列腺切除术后膀胱颈挛缩的控尿效果及文献复习。

Continence outcomes after treatment of recalcitrant postprostatectomy bladder neck contracture and review of the literature.

机构信息

Glickman Urologic and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH.

Glickman Urologic and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH.

出版信息

Urology. 2014 Mar;83(3):648-52. doi: 10.1016/j.urology.2013.10.042. Epub 2013 Dec 21.

Abstract

OBJECTIVE

To present our experience with 2-stage management for recalcitrant refractory bladder neck contracture (BNC) after radical prostatectomy.

METHODS

A 15-year retrospective medical record review was performed for patients referred for BNC using current procedural terminology code or by International Classification of Diseases-Ninth Revision code for bladder neck incision (BNI). Treatment consisted of deep cold-knife BNI, followed by cystoscopy at 3-4 months. If stable and healed, an artificial urethral sphincter (AUS) or male sling was placed depending on continence level. Recurrent BNC at 3 months was treated with a second BNI.

RESULTS

Sixty-three patients were referred with median (range) age of 66 (41-82) years, body mass index 30.1 (21.9-64.8) kg/m(2), and follow-up of 11 (1-144) months. Seventeen (27%) underwent adjuvant radiation therapy. Of the 46 who had successful management of the BNC, 91.3% were satisfied with level of continence after BNI alone or with a single additional operation. Of the 33 who underwent AUS or sling, only 2 failures occurred: 1 ultimately required cystectomy after multiple urethral erosions, and 1 with mild incontinence was satisfied with a secondary sling procedure. Four patients progressed to permanent urinary diversion. Together, either BNI (n = 4) or the secondary incontinence procedure (n = 1) was not successful in a total of 5 patients and required permanent urinary diversion. Nine had concurrent severe membranous strictures with no coaptation of the external urethral sphincter and were treated with direct vision internal urethrotomy and AUS and were continent.

CONCLUSION

This represents the largest known experience with BNC after radical prostatectomy. Patients can be managed with cold-knife incision, followed by AUS or sling, with 66% achieving continence.

摘要

目的

介绍我们在根治性前列腺切除术后难治性难治性膀胱颈挛缩(BNC)的两阶段治疗经验。

方法

对因当前程序术语代码或国际疾病分类第九版膀胱颈切开术(BNI)代码而转至 BNC 的患者进行了 15 年的回顾性病历回顾。治疗包括深冷刀 BNI,然后在 3-4 个月时进行膀胱镜检查。如果稳定且愈合,则根据控尿水平放置人工尿道括约肌(AUS)或男性吊带。3 个月时出现复发性 BNC,采用第二次 BNI 治疗。

结果

63 例患者中位(范围)年龄为 66(41-82)岁,体重指数为 30.1(21.9-64.8)kg/m2,随访时间为 11(1-144)个月。17 例(27%)接受辅助放疗。在 46 例成功治疗 BNC 的患者中,91.3%对 BNI 单独或单次附加手术后的控尿水平满意。在 33 例接受 AUS 或吊带的患者中,仅发生 2 例失败:1 例最终因多次尿道侵蚀而需要行膀胱切除术,1 例轻度尿失禁患者对二次吊带手术满意。4 例患者进展为永久性尿流改道。总的来说,4 例患者因 BNI(n=4)或二次失禁手术(n=1)治疗失败,需要永久性尿流改道。9 例伴有严重膜性狭窄,外尿道括约肌无法吻合,采用直视下经尿道内切开术和 AUS 治疗,且保持控尿。

结论

这是迄今为止已知的根治性前列腺切除术后 BNC 最大规模的经验。患者可以通过冷刀切开,然后使用 AUS 或吊带进行治疗,66%的患者可以获得控尿。

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