Marchi Saverio, Pinton Paolo
Signal Transduction Lab, c/o CUBO, via Fossato di Mortara 70, I-44121 Ferrara, Italy.
J Physiol. 2014 Mar 1;592(5):829-39. doi: 10.1113/jphysiol.2013.268235. Epub 2013 Dec 23.
Although it has long been known that mitochondria take up Ca2+, the molecular identities of the channels and transporters involved in this process were revealed only recently. Here, we discuss the recent work that has led to the characterization of the mitochondrial calcium uniporter complex, which includes the channel-forming subunit MCU (mitochondrial calcium uniporter) and its regulators MICU1, MICU2, MCUb, EMRE, MCUR1 and miR-25. We review not only the biochemical identities and structures of the proteins required for mitochondrial Ca2+ uptake but also their implications in different physiopathological contexts.
尽管人们早就知道线粒体能够摄取Ca2+，但参与这一过程的通道和转运体的分子身份直到最近才被揭示。在此，我们讨论了最近的研究工作，这些工作促成了线粒体钙单向转运体复合物的特性描述，该复合物包括形成通道的亚基MCU（线粒体钙单向转运体）及其调节因子MICU1、MICU2、MCUb、EMRE、MCUR1和miR-25。我们不仅回顾了线粒体摄取Ca2+所需蛋白质的生化特性和结构，还探讨了它们在不同生理病理背景下的意义。
