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患者种族对与开具 HIV 暴露前预防 (PrEP) 相关的临床决策的影响:关于性风险补偿的假设及其对获取途径的影响。

The impact of patient race on clinical decisions related to prescribing HIV pre-exposure prophylaxis (PrEP): assumptions about sexual risk compensation and implications for access.

机构信息

Center for Interdisciplinary Research on AIDS, Yale University, 135 College Street, Suite 200, New Haven, CT, 06510, USA,

出版信息

AIDS Behav. 2014 Feb;18(2):226-40. doi: 10.1007/s10461-013-0675-x.

DOI:10.1007/s10461-013-0675-x
PMID:24366572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3983275/
Abstract

Antiretroviral pre-exposure prophylaxis (PrEP) has received increasing recognition as a viable prescription-based intervention for people at risk for HIV acquisition. However, little is known about racial biases affecting healthcare providers' willingness to prescribe PrEP. This investigation sought to explore medical students' stereotypes about sexual risk compensation among Black versus White men who have sex with men seeking PrEP, and the impact of such stereotypes on willingness to prescribe PrEP. An online survey presented participants (n = 102) with a clinical vignette of a PrEP-seeking, HIV-negative man with an HIV-positive male partner. Patient race was systematically manipulated. Participants reported predictions about patient sexual risk compensation, willingness to prescribe PrEP, and other clinical judgments. Bootstrapping analyses revealed that the Black patient was rated as more likely than the White patient to engage in increased unprotected sex if prescribed PrEP, which, in turn, was associated with reduced willingness to prescribe PrEP to the patient.

摘要

抗逆转录病毒药物事前预防(PrEP)作为一种针对艾滋病毒感染风险人群的可行的基于处方的干预措施,已得到越来越多的认可。然而,对于影响医疗保健提供者开处方 PrEP 的意愿的种族偏见,人们知之甚少。本研究旨在探索医学生对寻求 PrEP 的黑人和白人男男性行为者的性风险补偿的刻板印象,以及这种刻板印象对开处方 PrEP 的意愿的影响。一项在线调查向 102 名参与者(n=102)提供了一个 PrEP 寻求者、艾滋病毒阴性的男性与艾滋病毒阳性的男性伴侣的临床案例。患者的种族被系统地操纵。参与者报告了对患者性风险补偿、开处方 PrEP 的意愿和其他临床判断的预测。引导分析显示,与白人患者相比,黑人患者如果开了 PrEP,更有可能增加无保护性行为,而这反过来又与降低了向患者开处方 PrEP 的意愿有关。

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本文引用的文献

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Sexual behaviour of heterosexual men and women receiving antiretroviral pre-exposure prophylaxis for HIV prevention: a longitudinal analysis.接受抗逆转录病毒药物预防艾滋病的异性恋男性和女性的性行为:一项纵向分析。
Lancet Infect Dis. 2013 Dec;13(12):1021-8. doi: 10.1016/S1473-3099(13)70226-3. Epub 2013 Oct 17.
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Suboptimal awareness and comprehension of published preexposure prophylaxis efficacy results among physicians in Massachusetts.马萨诸塞州医生对已发表的暴露前预防效果结果的认知和理解欠佳。
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Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial.在曼谷泰国注射吸毒者中预防艾滋病毒感染的抗逆转录病毒预防(曼谷替诺福韦研究):一项随机、双盲、安慰剂对照的 3 期临床试验。
Lancet. 2013 Jun 15;381(9883):2083-90. doi: 10.1016/S0140-6736(13)61127-7. Epub 2013 Jun 13.
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Update to Interim Guidance for Preexposure Prophylaxis (PrEP) for the Prevention of HIV Infection: PrEP for injecting drug users.暴露前预防(PrEP)用于预防 HIV 感染的临时指南更新:为注射吸毒者提供 PrEP。
MMWR Morb Mortal Wkly Rep. 2013 Jun 14;62(23):463-5.
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Knowledge of and opinions on HIV preexposure prophylaxis among front-line service providers at Canadian AIDS service organizations.加拿大艾滋病服务组织一线服务提供者对HIV暴露前预防的了解与看法。
AIDS Res Hum Retroviruses. 2013 Sep;29(9):1183-9. doi: 10.1089/aid.2013.0090. Epub 2013 Jun 22.
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Ethical use of antiretroviral resources for HIV prevention in resource poor settings.在资源匮乏环境下,艾滋病毒预防中抗逆转录病毒资源的合理使用。
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Antiretroviral resource allocation for HIV prevention.用于艾滋病预防的抗逆转录病毒资源分配
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A social psychological approach to improving the outcomes of racially discordant medical interactions.一种改善种族不和谐医疗互动结果的社会心理方法。
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