选择性阻断雌激素受体β可改善糖尿病患者的伤口愈合。 - Suppr

Selective blockade of estrogen receptor beta improves wound healing in diabetes.

作者信息

Sunkari Vivekananda Gupta, Botusan Ileana R, Savu Octavian, Grünler Jacob, Zheng Xiaowei, Gustafsson Jan-Åke, Brismar Kerstin, Catrina Sergiu-Bogdan

机构信息

Department of Molecular Medicine and Surgery, Karolinska Institutet, Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska University Hospital Solna, L1:01, 17176, Stockholm, Sweden.

出版信息

Endocrine. 2014 Jun;46(2):347-50. doi: 10.1007/s12020-013-0144-3. Epub 2013 Dec 24.

DOI:10.1007/s12020-013-0144-3

PMID:24366647

Abstract

摘要

相似文献

Selective blockade of estrogen receptor beta improves wound healing in diabetes.选择性阻断雌激素受体β可改善糖尿病患者的伤口愈合。

Endocrine. 2014 Jun;46(2):347-50. doi: 10.1007/s12020-013-0144-3. Epub 2013 Dec 24.

Advantages in Wound Healing Process in Female Mice Require Upregulation A-Mediated Angiogenesis under the Stimulation of 17β-Estradiol.在 17β-雌二醇刺激下，A 调节的血管生成要求上调，这有利于雌性小鼠的伤口愈合过程。

Int J Mol Sci. 2020 Sep 28;21(19):7145. doi: 10.3390/ijms21197145.

17β-estradiol lowers triglycerides in adipocytes via estrogen receptor α and it may be attenuated by inflammation.17β-雌二醇通过雌激素受体 α 降低脂肪细胞中的甘油三酯，而炎症可能会减弱这种作用。

Lipids Health Dis. 2017 Sep 25;16(1):182. doi: 10.1186/s12944-017-0575-6.

17β-Estradiol upregulates ecto-5'-nucleotidase (CD73) in hippocampal synaptosomes of female rats through action mediated by estrogen receptor-α and -β.17β-雌二醇通过雌激素受体-α和-β介导的作用上调雌性大鼠海马突触体中的ecto-5'-核苷酸酶（CD73）。

Neuroscience. 2016 Jun 2;324:286-96. doi: 10.1016/j.neuroscience.2016.03.022. Epub 2016 Mar 14.

Estrogen receptor ERα plays a major role in ethanol-evoked myocardial oxidative stress and dysfunction in conscious female rats.雌激素受体ERα在乙醇诱发的清醒雌性大鼠心肌氧化应激和功能障碍中起主要作用。

Alcohol. 2016 Feb;50:27-35. doi: 10.1016/j.alcohol.2015.11.002. Epub 2015 Nov 26.

Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-α and -β.雌二醇和睾酮通过雌激素受体-α 和 -β 调节 SH-SY5Y 人神经母细胞瘤细胞中的精氨酸加压素表达。

Endocrinology. 2013 Jun;154(6):2092-100. doi: 10.1210/en.2012-2137. Epub 2013 Apr 12.

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.具有碱性侧链的吡唑并嘧啶类化合物雌激素受体结合亲和力和拮抗剂活性的结构导向优化

J Med Chem. 2007 Jan 25;50(2):399-403. doi: 10.1021/jm061035y.

Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing.雌激素受体-α和-β的药理学激活对角质形成细胞分化有不同调节作用，并对伤口愈合产生功能性影响。

Int J Mol Med. 2016 Jan;37(1):21-8. doi: 10.3892/ijmm.2015.2351. Epub 2015 Sep 21.

Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol.芒果苷和槲皮素的雌激素调节特性及芒果苷代谢产物诺马孕醇。

Food Funct. 2015 Jun;6(6):1847-54. doi: 10.1039/c5fo00133a.

Expression of estrogen and progesterone receptors across human malignancies: new therapeutic opportunities.雌激素和孕激素受体在人类恶性肿瘤中的表达：新的治疗机遇

Cancer Metastasis Rev. 2015 Dec;34(4):547-61. doi: 10.1007/s10555-014-9543-z.

引用本文的文献

Topical estrogen application promotes cutaneous wound healing in db/db female mice with type 2 diabetes.局部应用雌激素可促进 2 型糖尿病 db/db 雌性小鼠皮肤伤口愈合。

PLoS One. 2022 Mar 10;17(3):e0264572. doi: 10.1371/journal.pone.0264572. eCollection 2022.

Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate.肝源性胰岛素样生长因子-I（IGF-I）缺乏并不影响皮肤伤口愈合速度。

PLoS One. 2018 Mar 13;13(3):e0193084. doi: 10.1371/journal.pone.0193084. eCollection 2018.

Evaluation of Effects of Topical Estradiol Benzoate Application on Cutaneous Wound Healing in Ovariectomized Female Mice.评估局部应用苯甲酸雌二醇对去卵巢雌性小鼠皮肤伤口愈合的影响。

PLoS One. 2016 Sep 22;11(9):e0163560. doi: 10.1371/journal.pone.0163560. eCollection 2016.

本文引用的文献

17ß-estradiol antagonizes the down-regulation of ERα/NOS-3 signaling in vascular endothelial dysfunction of female diabetic rats.17β-雌二醇拮抗雌性糖尿病大鼠血管内皮功能障碍中 ERα/NOS-3 信号的下调。

PLoS One. 2012;7(11):e50402. doi: 10.1371/journal.pone.0050402. Epub 2012 Nov 29.

β-LGND2, an ERβ selective agonist, inhibits pathologic retinal neovascularization.β-LGND2，一种 ERβ 选择性激动剂，可抑制病理性视网膜新生血管形成。

Invest Ophthalmol Vis Sci. 2012 Jul 31;53(8):5066-75. doi: 10.1167/iovs.12-9627.

Diagnostics and treatment of the diabetic foot.糖尿病足的诊断与治疗。

Endocrine. 2012 Jun;41(3):384-97. doi: 10.1007/s12020-012-9619-x. Epub 2012 Feb 25.

Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes.在2型糖尿病雌性大鼠模型中，转化生长因子-β（TGF-β）信号传导受损以及炎症消退缺陷导致伤口愈合延迟。

Mol Biosyst. 2011 Nov;7(11):3006-20. doi: 10.1039/c0mb00317d. Epub 2011 Aug 18.

Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities.雌激素通过雌激素受体 β 促进皮肤伤口愈合，而不依赖其抗炎活性。

J Exp Med. 2010 Aug 30;207(9):1825-33. doi: 10.1084/jem.20100500. Epub 2010 Aug 23.

Estrogen receptors and endothelium.雌激素受体与内皮。

Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1506-12. doi: 10.1161/ATVBAHA.109.191221.

ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.ERβ 通过使 HIF-1α 不稳定并抑制 VEGF 介导的 snail 核定位来阻碍前列腺癌 EMT：对 Gleason 分级的影响。

Cancer Cell. 2010 Apr 13;17(4):319-32. doi: 10.1016/j.ccr.2010.02.030.

Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice.缺氧诱导因子-1α（HIF-1α）的稳定对于改善糖尿病小鼠的伤口愈合至关重要。

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19426-31. doi: 10.1073/pnas.0805230105. Epub 2008 Dec 4.

Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response.局部用雌激素可加速老年人类皮肤伤口愈合，且与炎症反应改变有关。

Am J Pathol. 1999 Oct;155(4):1137-46. doi: 10.1016/S0002-9440(10)65217-0.

Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels.雌激素通过增加转化生长因子β1（TGF-β1）水平来加速皮肤伤口愈合。

Nat Med. 1997 Nov;3(11):1209-15. doi: 10.1038/nm1197-1209.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Selective blockade of estrogen receptor beta improves wound healing in diabetes.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献