Sciancalepore Francesco, Tariciotti Leonardo, Remoli Giulia, Menegatti Danilo, Carai Andrea, Petruzzellis Giuseppe, Miller Kiersten P, Delli Priscoli Francesco, Giuseppi Alessandro, Premuselli Roberto, Tozzi Alberto E, Mastronuzzi Angela, Vanacore Nicola, Lacorte Eleonora, Group Allena-Mente Study
National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, 00161 Rome, Italy.
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Unit of Neurosurgery, 20122 Milan, Italy.
Cancers (Basel). 2022 Aug 11;14(16):3879. doi: 10.3390/cancers14163879.
Late neurocognitive sequelae are common among long-term brain tumour survivors, resulting in significantly worse quality of life. Cognitive rehabilitation through specific APP/software for PC/tablets represents an innovative intervention spreading in recent years. In this study, we aim to review the current evidence and trends regarding these innovative approaches. : A systematic literature review was performed. Inclusion criteria were: (i) Studies recruiting patients diagnosed with any brain tumour before 21 years of age; (ii) studies assessing the role of digital interventions on cognitive outcomes. Case reports, case series, reviews, letters, conference proceedings, abstracts, and editorials were excluded. Overall, nine studies were included; 152 patients (67.8% males) with brain tumours underwent a digital intervention. The mean age at diagnosis and the intervention enrolment ranged from 4.9 to 9.4 years and 11.1 to 13.3 years, respectively. The computer-based software interventions employed were: Cogmed, Captain's Log, Fast ForWord, and Nintendo Wii. Most of these studies assessed the effects of cognitive training on working memory, attention, and performance in daily living activities. The studies suggest that this type of intervention improves cognitive functions, such as working memory, attention, and processing speed. However, some studies revealed only transient positive effects with a significant number of dropouts during follow-up. Trials with greater sample sizes are warranted. Motivating families and children to complete cognitive interventions could significantly improve cognitive outcomes and quality of life.
晚期神经认知后遗症在长期脑肿瘤幸存者中很常见，会导致生活质量显著下降。通过针对个人电脑/平板电脑的特定应用程序/软件进行认知康复是近年来一种新兴的干预方式。在本研究中，我们旨在综述有关这些创新方法的现有证据和趋势。我们进行了一项系统的文献综述。纳入标准为：（i）招募21岁之前被诊断患有任何脑肿瘤患者的研究；（ii）评估数字干预对认知结果作用的研究。排除病例报告、病例系列、综述、信函、会议论文集、摘要和社论。总体而言，共纳入9项研究；152例脑肿瘤患者（67.8%为男性）接受了数字干预。诊断时的平均年龄和干预入组时的平均年龄分别为4.9至9.4岁和11.1至13.3岁。所采用的基于计算机的软件干预措施包括：Cogmed、Captain's Log、Fast ForWord和任天堂Wii。这些研究大多评估了认知训练对工作记忆、注意力和日常生活活动表现的影响。研究表明，这类干预可改善认知功能，如工作记忆、注意力和处理速度。然而，一些研究仅显示出短暂的积极效果，且随访期间有大量患者退出。有必要开展更大样本量的试验。激励家庭和儿童完成认知干预可显著改善认知结果和生活质量。
