金纽扣的植物化学、药理学与毒理学综述
Phytochemistry, Pharmacology and Toxicology of Spilanthes acmella: A Review.
作者信息
Dubey Suchita, Maity Siddhartha, Singh Mahendra, Saraf Shubhini A, Saha Sudipta
机构信息
Department of Pharmaceutical Sciences, School of Bioscience and Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh 226025, India.
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India.
出版信息
Adv Pharmacol Sci. 2013;2013:423750. doi: 10.1155/2013/423750. Epub 2013 Nov 26.
Abstract
Spilanthes acmella is an important medicinal plant, found in tropical and subtropical countries mainly India and South America. Popularly, it is known as toothache plant which reduces the pain associated with toothaches and can induce saliva secretion. Various extracts and active metabolites from various parts of this plant possess useful pharmacological activities. Literature survey proposed that it has multiple pharmacological actions, which include antifungal, antipyretic, local anaesthetic, bioinsecticide, anticonvulsant, antioxidant, aphrodisiac, analgesic, pancreatic lipase inhibitor, antimicrobial, antinociception, diuretic, vasorelaxant, anti-human immunodeficiency virus, toothache relieve and anti-inflammatory effects. This review is elaborately describing the traditional uses, phytochemistry, pharmacology, and toxicology of this plant. This review would assist researchers to search scientific information in the future.
摘要
金纽扣是一种重要的药用植物，主要分布在热带和亚热带国家，如印度和南美洲。通常，它被称为牙痛草，能减轻与牙痛相关的疼痛并能促进唾液分泌。该植物各部位的各种提取物和活性代谢物具有有益的药理活性。文献调查表明它具有多种药理作用，包括抗真菌、解热、局部麻醉、生物杀虫剂、抗惊厥、抗氧化、壮阳、止痛、胰腺脂肪酶抑制、抗菌、抗伤害感受、利尿、血管舒张、抗人类免疫缺陷病毒、缓解牙痛和抗炎作用。本综述详细描述了这种植物的传统用途、植物化学、药理学和毒理学。本综述将有助于研究人员在未来查找科学信息。
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本文引用的文献
1
Pungent Alkamides from Spilanthes acmella L. var. oleracea Clarke.来自金纽扣变种（Spilanthes acmella L. var. oleracea Clarke.）的辛辣酰胺类化合物
Biosci Biotechnol Biochem. 1992 Jan;56(5):759-62. doi: 10.1271/bbb.56.759.
2
Spilanthes acmella ethanolic flower extract: LC-MS alkylamide profiling and its effects on sexual behavior in male rats.荆芥薁醇提花提取物的 LC-MS 烷基酰胺成分分析及其对雄性大鼠性行为的影响。
Phytomedicine. 2011 Oct 15;18(13):1161-9. doi: 10.1016/j.phymed.2011.06.001. Epub 2011 Jul 16.
3
Ethnobotany of religious and supernatural beliefs of the Mising tribes of Assam with special reference to the 'Dobur Uie'.阿萨姆米辛部落的宗教和超自然信仰的民族植物学，特别提到“Dobur Uie”。
J Ethnobiol Ethnomed. 2011 Jun 2;7:16. doi: 10.1186/1746-4269-7-16.
4
Preliminary studies on local anesthetic and antipyretic activities of Spilanthes acmella Murr. in experimental animal models.在实验动物模型中研究斯潘德相思（Spilanthes acmella Murr.）的局部麻醉和解热活性的初步研究。
Indian J Pharmacol. 2010 Oct;42(5):277-9. doi: 10.4103/0253-7613.70106.
5
LC-MS profiling of N-alkylamides in Spilanthes acmella extract and the transmucosal behaviour of its main bio-active spilanthol.LC-MS 分析荆芥挥发油中的 N-烷基酰胺及其主要生物活性成分荆芥醇的经黏膜行为。
J Pharm Biomed Anal. 2010 Nov 2;53(3):243-9. doi: 10.1016/j.jpba.2010.02.010. Epub 2010 Feb 13.
6
Vasorelaxant and antioxidant activities of Spilanthes acmella Murr.小花金纽扣的血管舒张和抗氧化活性
Int J Mol Sci. 2008 Dec;9(12):2724-2744. doi: 10.3390/ijms9122724. Epub 2008 Dec 18.
7
Bioactive metabolites from Spilanthes acmella Murr.来自小花金纽扣的生物活性代谢产物
Molecules. 2009 Feb 19;14(2):850-67. doi: 10.3390/molecules14020850.
8
Anti-inflammatory effect of spilanthol from Spilanthes acmella on murine macrophage by down-regulating LPS-induced inflammatory mediators.来自金纽扣的毛叶花椒酰胺通过下调脂多糖诱导的炎症介质对小鼠巨噬细胞的抗炎作用
J Agric Food Chem. 2008 Apr 9;56(7):2341-9. doi: 10.1021/jf073057e. Epub 2008 Mar 6.
9
Antiobesity properties of two African plants (Afromomum meleguetta and Spilanthes acmella) by pancreatic lipase inhibition.两种非洲植物（非洲豆蔻和金纽扣）通过抑制胰脂肪酶发挥的抗肥胖特性。
Phytother Res. 2007 Dec;21(12):1253-5. doi: 10.1002/ptr.2239.
10
Isolation and synthesis of acmellonate, a new unsaturated long chain 2-ketol ester from Spilanthes acmella.从金纽扣中分离并合成新的不饱和长链2-酮醇酯——金纽扣酸酯。
Nat Prod Res. 2006 Jul 20;20(9):798-804. doi: 10.1080/14786410500246733.
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