Ramireddy Sweeya, Wanger Audrey, Ostrosky Luis
Division of Infectious Diseases, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 2.112, Houston, Texas 77030, USA.
Med Mycol Case Rep. 2012 Aug 28;1(1):69-71. doi: 10.1016/j.mmcr.2012.08.002. eCollection 2012.
Histoplasma capsulatum is a dimorphic endemic fungus which infects both immunocompetent and immunocompromised hosts. Isolated CNS histoplasmosis is a rare presentation with increased risk in individuals with impaired cellular immunity, however not all patients with this condition are immunocompromised. We report a case of isolated CNS histoplasmosis in an otherwise healthy immunocompetent patient who was initially treated with Liposomal Amphotericin B followed by oral Voriconazole and later Itraconazole with significant improvement in clinical status.
荚膜组织胞浆菌是一种双相性地方真菌，可感染免疫功能正常和免疫功能低下的宿主。孤立性中枢神经系统组织胞浆菌病是一种罕见的表现形式，在细胞免疫受损的个体中风险增加，然而并非所有患有这种疾病的患者都是免疫功能低下的。我们报告一例孤立性中枢神经系统组织胞浆菌病病例，患者为一名原本健康的免疫功能正常者，最初接受脂质体两性霉素B治疗，随后口服伏立康唑，后来又使用伊曲康唑，临床状况有显著改善。
