Mitalipov Shoukhrat, Wolf Don P
Oregon National Primate Research Center, Oregon Health and Science University, 505 North West 185th Avenue, Beaverton, OR 97006, USA.
Oregon National Primate Research Center, Oregon Health and Science University, 505 North West 185th Avenue, Beaverton, OR 97006, USA.
Trends Endocrinol Metab. 2014 Jan;25(1):5-7. doi: 10.1016/j.tem.2013.09.001.
Inherited diseases caused by mitochondrial gene (mtDNA) mutations affect at least 1 in 5000-10,000 children and are associated with severe clinical symptoms. Novel reproductive techniques designed to replace mutated mtDNA in oocytes or early embryos have been proposed to prevent transmission of disease from parents to their children. Here we review the efficacy and safety of these approaches and their associated ethical and regulatory issues.
由线粒体基因（mtDNA）突变引起的遗传性疾病影响着至少五千分之一至一万分之一的儿童，并伴有严重的临床症状。为防止疾病从父母传给子女，人们提出了旨在替换卵母细胞或早期胚胎中突变mtDNA的新型生殖技术。在此，我们综述了这些方法的有效性和安全性及其相关的伦理和监管问题。
