Li Jiwei, Huang Sha, Wu Yan, Gu Chengwei, Gao Dongyun, Feng Changjiang, Wu Xu, Fu Xiaobing
Department of Thoracic and Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, P. R. China; Key Laboratory of Wound Repair and Regeneration of PLA, The First Affiliated Hospital, General Hospital of PLA, Trauma Center of Postgraduate Medical College, Beijing, P. R. China.
Int Wound J. 2014 Apr;11(2):114-21. doi: 10.1111/iwj.12202. Epub 2013 Dec 26.
Despite extensive researches in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), current pharmacological therapies and respiratory support are still the main methods to treat patients with ALI and ARDS and the effects remain limited. Hence, innovative therapies are needed to decrease the morbidity and mortality. Because of the proven therapeutic effects in other fields, mesenchymal stem cells (MSCs) might be considered as a promising alternative to treat ALI and ARDS. Numerous documents demonstrate that MSCs can exert multiple functions, such as engraftment, differentiation and immunoregulation, but now the key researches are concentrated on paracrine factors secreted by MSCs that can mediate endothelial and epithelial permeability, increase alveolar fluid clearance and other potential mechanisms. This review aimed to review the current researches in terms of the effects of MSCs on ALI and ARDS and to analyse these paracrine factors, as well as to predict the potential directions and challenges of the application in this field.
尽管在急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）方面进行了广泛研究，但目前的药物治疗和呼吸支持仍然是治疗ALI和ARDS患者的主要方法，且效果仍然有限。因此，需要创新疗法来降低发病率和死亡率。由于间充质干细胞（MSCs）在其他领域已被证实具有治疗效果，它可能被视为治疗ALI和ARDS的一种有前景的替代方法。众多文献表明，MSCs可以发挥多种功能，如植入、分化和免疫调节，但目前关键研究集中在MSCs分泌的旁分泌因子上，这些因子可介导内皮和上皮通透性、增加肺泡液体清除率及其他潜在机制。这篇综述旨在回顾目前关于MSCs对ALI和ARDS影响的研究，分析这些旁分泌因子，并预测该领域应用的潜在方向和挑战。
