Engel Stacia R, Dietrich Fred S, Fisk Dianna G, Binkley Gail, Balakrishnan Rama, Costanzo Maria C, Dwight Selina S, Hitz Benjamin C, Karra Kalpana, Nash Robert S, Weng Shuai, Wong Edith D, Lloyd Paul, Skrzypek Marek S, Miyasato Stuart R, Simison Matt, Cherry J Michael
Department of Genetics, Stanford University, Stanford, California 94305.
G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
The genome of the budding yeast Saccharomyces cerevisiae was the first completely sequenced from a eukaryote. It was released in 1996 as the work of a worldwide effort of hundreds of researchers. In the time since, the yeast genome has been intensively studied by geneticists, molecular biologists, and computational scientists all over the world. Maintenance and annotation of the genome sequence have long been provided by the Saccharomyces Genome Database, one of the original model organism databases. To deepen our understanding of the eukaryotic genome, the S. cerevisiae strain S288C reference genome sequence was updated recently in its first major update since 1996. The new version, called "S288C 2010," was determined from a single yeast colony using modern sequencing technologies and serves as the anchor for further innovations in yeast genomic science.
芽殖酵母酿酒酵母的基因组是首个从真核生物中完全测序得到的基因组。它于1996年发布，是数百名研究人员全球合作的成果。自那以后，酵母基因组受到了世界各地遗传学家、分子生物学家和计算科学家的深入研究。基因组序列的维护和注释长期以来一直由酿酒酵母基因组数据库提供，该数据库是最初的模式生物数据库之一。为了加深我们对真核生物基因组的理解，酿酒酵母菌株S288C的参考基因组序列最近进行了自1996年以来的首次重大更新。新版本称为“S288C 2010”，是使用现代测序技术从单个酵母菌落中确定的，作为酵母基因组科学进一步创新的基础。
