Department of Genetics, Stanford University, Stanford, CA, USA.
Database (Oxford). 2013 Mar 13;2013:bat012. doi: 10.1093/database/bat012. Print 2013.
The first completed eukaryotic genome sequence was that of the yeast Saccharomyces cerevisiae, and the Saccharomyces Genome Database (SGD; http://www.yeastgenome.org/) is the original model organism database. SGD remains the authoritative community resource for the S. cerevisiae reference genome sequence and its annotation, and continues to provide comprehensive biological information correlated with S. cerevisiae genes and their products. A diverse set of yeast strains have been sequenced to explore commercial and laboratory applications, and a brief history of those strains is provided. The publication of these new genomes has motivated the creation of new tools, and SGD will annotate and provide comparative analyses of these sequences, correlating changes with variations in strain phenotypes and protein function. We are entering a new era at SGD, as we incorporate these new sequences and make them accessible to the scientific community, all in an effort to continue in our mission of educating researchers and facilitating discovery.
第一个完成的真核生物基因组序列是酵母酿酒酵母，而酿酒酵母基因组数据库（SGD；http://www.yeastgenome.org/）是最初的模式生物数据库。SGD 仍然是酿酒酵母参考基因组序列及其注释的权威社区资源，并继续提供与酿酒酵母基因及其产物相关的综合生物学信息。已经对多种酵母菌株进行了测序，以探索商业和实验室应用，并且提供了这些菌株的简要历史。这些新基因组的发表激发了新工具的创建，SGD 将对这些序列进行注释和比较分析，将变化与菌株表型和蛋白质功能的变化相关联。随着我们整合这些新序列并使其可供科学界使用，我们正在 SGD 进入一个新时代，所有这些都是为了继续我们的使命，即教育研究人员并促进发现。
