对一家微电子和商业机器工厂的回顾性队列研究。
Retrospective cohort study of a microelectronics and business machine facility.
作者信息
Silver Sharon R, Pinkerton Lynne E, Fleming Donald A, Jones James H, Allee Steven, Luo Lian, Bertke Stephen J
机构信息
Division of Surveillance, Hazard Assessment and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
出版信息
Am J Ind Med. 2014 Apr;57(4):412-24. doi: 10.1002/ajim.22288. Epub 2013 Dec 24.
OBJECTIVES
We examined health outcomes among 34,494 workers employed at a microelectronics and business machine facility 1969-2001.
METHODS
Standardized mortality ratio (SMR) and standardized incidence ratios were used to evaluate health outcomes in the cohort and Cox regression modeling to evaluate relations between scores for occupational exposures and outcomes of a priori interest.
RESULTS
Just over 17% of the cohort (5,966 people) had died through 2009. All cause, all cancer, and many cause-specific SMRs showed statistically significant deficits. In hourly males, SMRs were significantly elevated for non-Hodgkin's lymphoma and rectal cancer. Salaried males had excess testicular cancer incidence. Pleural cancer and mesothelioma excesses were observed in workers hired before 1969, but no available records substantiate use of asbestos in manufacturing processes. A positive, statistically significant relation was observed between exposure scores for tetrachloroethylene and nervous system diseases.
CONCLUSIONS
Few significant exposure-outcome relations were observed, but risks from occupational exposures cannot be ruled out due to data limitations and the relative youth of the cohort.
目的
我们研究了1969年至2001年期间受雇于一家微电子和商业机器工厂的34494名工人的健康结局。
方法
使用标准化死亡率（SMR）和标准化发病率来评估队列中的健康结局，并使用Cox回归模型评估职业暴露评分与先验感兴趣结局之间的关系。
结果
到2009年，队列中略超过17%（5966人）已死亡。全因、所有癌症以及许多特定病因的SMR均显示出统计学上的显著不足。在小时工男性中，非霍奇金淋巴瘤和直肠癌的SMR显著升高。受薪男性的睾丸癌发病率过高。在1969年之前受雇的工人中观察到胸膜癌和间皮瘤过多，但没有可用记录证实制造过程中使用了石棉。在四氯乙烯的暴露评分与神经系统疾病之间观察到了一种正向的、具有统计学意义的关系。
结论
观察到的显著暴露-结局关系较少，但由于数据限制和队列相对年轻，不能排除职业暴露带来的风险。
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