Department of Internal Medicine, University of Pittsburgh Medical Center , Pittsburgh, PA , USA.
Department of Epidemiology, Johns Hopkins School of Public Health , Baltimore, MD , USA.
Front Oncol. 2013 Dec 12;3:303. doi: 10.3389/fonc.2013.00303. eCollection 2013.
Cervical cancer is a leading cause of cancer mortality in South Africa. However, little is known about oral human papillomavirus (HPV) infection in high human immunodeficiency virus (HIV) seroprevalence settings.
Thirty-four adult heterosexual couples attending an HIV testing center in Soweto, South Africa were enrolled. Each participant provided an oral rinse sample and genital swab, which were tested for 37 types of HPV DNA, and completed a risk behavior survey.
Median age was 31 years and 9% (3/34) of men and 29% (10/34) of women enrolled tested HIV-positive; median CD4 count was 437 cells/mm(3). Oral HPV prevalence was similar in women and men (12 vs. 18%, p = 0.48), and was non-significantly higher in HIV-infected vs. HIV-uninfected (23 vs. 13%, p = 0.34) subjects. Most men (82%) and women (84%) reported ever performing oral sex. Median number of lifetime sexual partners was "2-5" while median number of lifetime oral sex partners was 1. Oncogenic HPV subtypes were detected in 4% of oral, 26% of penile, and 74% of vaginal samples, including HPV16 in 1, 12, and 21% of these samples respectively. Genital HPV prevalence was significantly higher than oral HPV prevalence (75 vs. 15%, p ≤ 0.001). Thirty-five percent of couples (12/34) had at least one type-specific concordant vaginal-penile HPV infection but only one of nine couples with oral HPV had concordant oral-oral infection. However, 67% (4/6) of men and 25% (1/4) of women with oral HPV infection had partners with concordant genital HPV infection. Implications and Impact: Oral-oral HPV concordance between couples is low, but oral-genital and genital-genital HPV concordance is higher, including concordance of male oral HPV infection with their partners' vaginal HPV infection. This data is consistent with possible transmission of vaginal HPV infection to the oral cavity of sexual partners performing oral sex.
宫颈癌是南非癌症死亡率的主要原因。然而，在高人类免疫缺陷病毒（HIV）血清流行率环境中，人们对口腔人乳头瘤病毒（HPV）感染知之甚少。
在南非索韦托的一个艾滋病毒检测中心招募了 34 对成年异性恋夫妇。每位参与者提供了口腔冲洗样本和生殖器拭子，用于检测 37 种 HPV DNA，并完成了风险行为调查。
中位年龄为 31 岁，9%（3/34）的男性和 29%（10/34）的女性入组时 HIV 检测呈阳性；中位 CD4 计数为 437 个细胞/mm³。女性和男性的口腔 HPV 流行率相似（12%比 18%，p=0.48），HIV 感染者的口腔 HPV 流行率非显著高于 HIV 未感染者（23%比 13%，p=0.34）。大多数男性（82%）和女性（84%）报告曾进行过口腔性行为。中位终生性伴侣数为“2-5”，中位终生口腔性伴侣数为 1。在 4%的口腔、26%的阴茎和 74%的阴道样本中检测到致癌 HPV 亚型，包括这些样本中分别有 1%、12%和 21%的 HPV16。生殖器 HPV 流行率显著高于口腔 HPV 流行率（75%比 15%，p≤0.001）。35%的夫妇（12/34）至少有一种特定型别的阴道-阴茎 HPV 感染一致，但仅有 1 对 9 对口腔 HPV 感染的夫妇存在口腔-口腔感染一致。然而，67%（4/6）的口腔 HPV 感染男性和 25%（1/4）的口腔 HPV 感染女性的伴侣有生殖器 HPV 感染一致。
夫妇之间的口腔-口腔 HPV 一致性较低，但口腔-生殖器和生殖器-生殖器 HPV 一致性较高，包括男性口腔 HPV 感染与性伴侣阴道 HPV 感染的一致性。这些数据与可能通过进行口腔性行为将阴道 HPV 感染传播给性伴侣的口腔相吻合。
Zotero 插件