Department of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, United States.
Cardiovascular Health Research Center, Sanford Research, Sioux Falls, SD, United States; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States; Department of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States.
Prostaglandins Leukot Essent Fatty Acids. 2014 Feb-Mar;90(2-3):69-75. doi: 10.1016/j.plefa.2013.12.003. Epub 2013 Dec 18.
The effects of dietary fatty acid supplementation on lipoprotein fatty acid composition have rarely been described.
Sixty-one overweight and obese adults with dyslipidemia and insulin resistance were randomized to placebo, 2g/day extended-release nicotinic acid (ERN), 4g/day prescription omega-3 fatty acid ethyl ester (P-OM3), or combination therapy for 16 weeks. Lipoprotein fatty acid composition was analyzed by gas chromatography pre- and post-treatment.
Treatment with P-OM3 or combination, but not ERN, increased proportions of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid, and reduced those for arachidonic acid in all lipoprotein fractions, with greatest impact in the high-density lipoprotein fraction. P-OM3-induced changes in eicosapentaenoic acid within low-density lipoproteins and very low-density lipoproteins were associated with beneficial effects on mean arterial pressure and pulse pressure.
P-OM3 supplementation, with or without ERN, was associated with differentially altered lipoprotein fatty acid composition and improved blood pressure parameters.
膳食脂肪酸补充对脂蛋白脂肪酸组成的影响鲜有报道。
61 名超重和肥胖的血脂异常及胰岛素抵抗患者随机分为安慰剂组、2g/天缓释烟酸（ERN）组、4g/天处方 ω-3 脂肪酸乙酯（P-OM3）组或联合治疗组，治疗 16 周。治疗前后用气相色谱法分析脂蛋白脂肪酸组成。
与 ERN 不同，P-OM3 或联合治疗可增加所有脂蛋白亚组份中二十碳五烯酸、二十二碳六烯酸和二十二碳五烯酸的比例，降低花生四烯酸的比例，高密度脂蛋白亚组份中变化最大。P-OM3 诱导的 LDL 和 VLDL 中二十碳五烯酸的变化与平均动脉压和脉压的有益变化相关。
P-OM3 补充，无论是否与 ERN 联合使用，均可引起脂蛋白脂肪酸组成的差异改变，并改善血压参数。
