Khodabandehloo Mazaher, Roshani Daem, Sayehmiri Kourosh
Department of Microbiology, Cellular and Molecular Research Center, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Kurdistan Research center for Social Determinants of Health (KRSCSDH), Kurdistan University of Medical Sciences, Sanandaj, Iran.
J Res Med Sci. 2013 Aug;18(8):674-82.
Hepatitis C virus (HCV) is the main causative agent of post-transfusion hepatitis. The virus is distributed worldwide with varying prevalence in different countries, which could easily lead to chronic infections, cirrhosis, and even hepatocellular carcinoma. The aim of this study was to investigate prevalence of HCV infection and its trend in Iranian blood donors.
Literatures on the HCV prevalence among blood donors in Iran were acquired through searching PubMed, Magiran, IranMedex, Scientific Information Databank, and Google databases. All the potentially relevant papers were reviewed independently by two investigators by assessing the eligibility of each paper and abstracting data. Prevalence was calculated using random effects model for meta-analysis.
Forty-eight studies with total samples of 10,739,221 persons from 1996 to 2011 were combined and meta-analyzed, the pooled prevalence of HCV infection among blood donors in Iran provinces and cities was 0.5% (95% CI: 0.4-0.6%). Trend of HCV infection was decreasing in recent years.
This study provides a comprehensive and reliable data on the prevalence and trend of HCV infection among blood donors and may be helpful in providing insight into disease burden and opportunities for prevention. In comparison with countries in this geographic region, Iran has the lowest rate of HCV infection.
丙型肝炎病毒（HCV）是输血后肝炎的主要病原体。该病毒在全球范围内分布，不同国家的流行率各不相同，很容易导致慢性感染、肝硬化甚至肝细胞癌。本研究的目的是调查伊朗献血者中HCV感染的流行率及其趋势。
通过检索PubMed、Magiran、IranMedex、科学信息数据库和谷歌数据库，获取有关伊朗献血者中HCV流行率的文献。两位研究人员通过评估每篇论文的合格性并提取数据，独立审查了所有潜在相关论文。使用随机效应模型进行荟萃分析计算流行率。
对1996年至2011年的48项研究进行合并和荟萃分析，这些研究的总样本量为10739221人，伊朗各省市献血者中HCV感染的合并流行率为0.5%（95%CI：0.4 - 0.6%）。近年来HCV感染趋势呈下降趋势。
本研究提供了关于献血者中HCV感染流行率和趋势的全面可靠数据，可能有助于深入了解疾病负担和预防机会。与该地理区域的国家相比，伊朗的HCV感染率最低。
