Department of Biochemistry, Faculty of Basic Science, Razi University, Kermanshah, Iran.
Student Research Committee, Sari University of Medical Sciences, Sari, Iran.
Arch Iran Med. 2018 Jun 1;21(6):260-267.
The probability of HIV transmission through contaminated blood and blood products is eye catching. 5%-10% of blood products are contaminated with HIV. Therefore, it is essential to provide safe blood supply to prevent transmission of infectious diseases. Current systematic review and meta-analysis was conducted to evaluate the weighted prevalence of HIV in Iranian blood donors.
This study was reported according to PRISMA checklist for systematic reviews and meta- analysis. Required data were collected by using key words such as "HIV", "blood donation" OR "blood donors", "epidemiology" OR "prevalence", "blood transfusion" and "Iran", in international databases including PubMed, Scopus, Web of Science, Cochrane, Embase and national databases including Magiran, IranMedex and Scientific Information Databank. Papers were searched until December 2017. Cochran's Q test and I index were used to assess the heterogeneity among studies.
A total of 49 studies including 5403170 donors entered this meta-analysis. According to analysis, the prevalence of HIV-positive patients among Iran blood donors was estimated 7.9/100000 (95% CI: 0.000052-0.000121%). The highest prevalence was related to the central region of Iran (11.3/100,000 [95% CI:0.000063-0.0002%]) and Kermanshah province (49.2/100000 [95% CI:0.000273-0.000888%]) and the lowest prevalence was related to the eastern region (1/100000 [95% CI:0.000001-0.000072%]) and Khorasan Razavi province (0.9/100000 [95% CI:0.000001-0.000139%].
The overall HIV prevalence in Iranian blood donors is low and satisfying. However, the high prevalence in some regions and provinces should be reviewed more meticulously.
经污染的血液和血液制品传播 HIV 的概率是引人注目的。5%-10%的血液制品会受到 HIV 污染。因此，提供安全的血液供应以防止传染病的传播至关重要。本系统评价和荟萃分析旨在评估伊朗献血者中 HIV 的加权流行率。
本研究根据系统评价和荟萃分析的 PRISMA 清单进行报告。通过使用“HIV”、“献血”或“献血者”、“流行病学”或“流行率”、“输血”和“伊朗”等关键词，从国际数据库（PubMed、Scopus、Web of Science、Cochrane、Embase）和国内数据库（Magiran、IranMedex 和 Scientific Information Databank）中收集所需数据。文献检索截止日期为 2017 年 12 月。使用 Cochran's Q 检验和 I 指数评估研究之间的异质性。
共有 49 项研究（共 5403170 名献血者）纳入本荟萃分析。分析显示，伊朗献血者中 HIV 阳性患者的患病率估计为 7.9/100000（95%CI：0.000052-0.000121%）。患病率最高的地区与伊朗的中部地区（11.3/100000 [95%CI：0.000063-0.0002%]）和克尔曼沙阿省（49.2/100000 [95%CI：0.000273-0.000888%]）有关，而患病率最低的地区与伊朗的东部地区（1/100000 [95%CI：0.000001-0.000072%]）和霍拉桑拉扎维省（0.9/100000 [95%CI：0.000001-0.000139%]）有关。
伊朗献血者中 HIV 的总体流行率较低且令人满意。然而，一些地区和省份的高患病率需要更仔细地审查。
