Ranken R, Kaplan M J, Silverman S, Gottfried T G, White C, Fee W E, Yonkovich S, Boles R, Liu V
Laryngoscope. 1987 Jun;97(6):657-62. doi: 10.1288/00005537-198706000-00001.
Monoclonal antibody 17.13.Cl.10 is a murine IgM kappa monoclonal antibody (Mab) that stains frozen section squamous cell carcinoma (SCC) homogeneously and intensely with a sensitivity greater than 98%, including 106/107 SCC specimens from the head and neck. It was produced using a human laryngeal SCC as immunogen and screened using frozen section human tissue. Monoclonal antibody 17.13.Cl.10 faintly stains the basal layer of normal squamous epithelium, does not stain normal organ tissue other than myoepithelial cells, and reacts with few non-SCC tumors. It, therefore, may be a useful adjunct to standard histopathologic criteria for the diagnosis of SCC. It may prove helpful in the investigation of tumor-associated antigens. Despite major technical and immunologic problems, monoclonal antibodies to functional tissue-specific tumor-associated antigens have the potential to play a major role in imaging and in treatment in the future.
单克隆抗体17.13.Cl.10是一种鼠源IgM κ单克隆抗体（Mab），对冰冻切片鳞状细胞癌（SCC）染色均匀且强烈，敏感性大于98%，包括106/107例来自头颈部的SCC标本。它是以人喉鳞状细胞癌作为免疫原产生的，并使用冰冻切片人体组织进行筛选。单克隆抗体17.13.Cl.10对正常鳞状上皮的基底层染色微弱，除肌上皮细胞外不染色正常器官组织，并且与少数非SCC肿瘤反应。因此，它可能是诊断SCC的标准组织病理学标准的有用辅助手段。它可能在肿瘤相关抗原的研究中被证明是有帮助的。尽管存在重大的技术和免疫学问题，但针对功能性组织特异性肿瘤相关抗原的单克隆抗体在未来的成像和治疗中有可能发挥重要作用。
