Quak J J, Van Dongen G, Brakkee J G, Hayashida D J, Balm A J, Snow G B, Meijer C J
Department of Otolaryngology/Head and Neck Surgery, Free University Hospital Amsterdam, The Netherlands.
Hybridoma. 1990 Aug;9(4):377-87. doi: 10.1089/hyb.1990.9.377.
During our efforts to develop monoclonal antibodies (MAbs) to tumor associated surface antigens of squamous cell carcinomas of the head and neck, monoclonal antibody K 931 was produced. The high affinity antibody (Ka 5.0 x 10(10) M-1) showed reactivity with 58 out of 62 squamous cell carcinomas of the head and neck. In contrast normal squamous epithelium as found in epidermis, oral cavity, epiglottis, pharynx, larynx and esophagus did not express the antigen. All other tested epithelial (simple and transitional) tissues did express the antigen, but non-epithelial tissues were negative. Further characterization revealed that the antigen represents the 17-1A antigen. A not earlier reported, enhanced expression of the 17-1A antigen was observed among some primary and all metastatic SCC.
在我们致力于开发针对头颈部鳞状细胞癌肿瘤相关表面抗原的单克隆抗体（MAb）的过程中，产生了单克隆抗体K 931。这种高亲和力抗体（Ka 5.0×10¹⁰ M⁻¹）与62例头颈部鳞状细胞癌中的58例有反应性。相比之下，在表皮、口腔、会厌、咽、喉和食管中发现的正常鳞状上皮不表达该抗原。所有其他测试的上皮（单层和移行）组织均表达该抗原，但非上皮组织为阴性。进一步的表征显示该抗原代表17-1A抗原。在一些原发性和所有转移性鳞状细胞癌中观察到了17-1A抗原此前未报道过的增强表达。
