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Selective killing effect of oxytetracycline, propafenone and metamizole on A549 or Hela cells.氧四环素、普罗帕酮和甲灭酸对 A549 或 Hela 细胞的选择性杀伤作用。
Chin J Cancer Res. 2013 Dec;25(6):662-70. doi: 10.3978/j.issn.1000-9604.2013.11.05.
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Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1.安乃近、甲氧基安乃近和对乙酰氨基酚对胰腺癌细胞系PaTu 8988 t和Panc-1增殖、凋亡及坏死的影响。
BMC Pharmacol Toxicol. 2017 Dec 6;18(1):77. doi: 10.1186/s40360-017-0185-y.
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Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction.普罗帕酮通过诱导线粒体功能障碍抑制食管癌增殖。
Am J Cancer Res. 2017 Nov 1;7(11):2245-2256. eCollection 2017.
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[Killing effect and its mechanism of low-temperature plasma on different human cancer cell lines].低温等离子体对不同人癌细胞系的杀伤作用及其机制
Zhonghua Zhong Liu Za Zhi. 2016 Oct 23;38(10):725-730. doi: 10.3760/cma.j.issn.0253-3766.2016.10.002.
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Acetaminophen and Metamizole Induce Apoptosis in HT 29 and SW 480 Colon Carcinoma Cell Lines .对乙酰氨基酚和安乃近诱导HT 29和SW 480结肠癌细胞系凋亡。
Anticancer Res. 2018 Feb;38(2):745-751. doi: 10.21873/anticanres.12280.
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Treatment of postoperative pain after total hip arthroplasty: comparison between metamizol and paracetamol as adjunctive to opioid analgesics-prospective, double-blind, randomised study.全髋关节置换术后疼痛的治疗：曲马朵与对乙酰氨基酚作为阿片类镇痛药辅助用药的比较——前瞻性、双盲、随机研究。
Arch Orthop Trauma Surg. 2014 May;134(5):631-6. doi: 10.1007/s00402-014-1979-7. Epub 2014 Mar 28.
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[Essential oil from Artemisia lavandulaefolia induces apoptosis and necrosis of HeLa cells].[薰衣草叶艾蒿精油诱导人宫颈癌HeLa细胞凋亡和坏死]
Zhong Yao Cai. 2013 Dec;36(12):1988-92.
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[Safety of metamizole and paracetamol for acute pain treatment].[安乃近与对乙酰氨基酚用于急性疼痛治疗的安全性]
Anestezjol Intens Ter. 2009 Jul-Sep;41(3):170-5.
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Metamizole limits proliferation in chronic myeloid leukemia cells and triggers apoptosis via the bax/bcl-2/caspase-3 cascade.安乃近可限制慢性髓性白血病细胞的增殖，并通过bax/bcl-2/半胱天冬酶-3级联反应触发细胞凋亡。
Med Oncol. 2025 Jun 27;42(8):288. doi: 10.1007/s12032-025-02842-x.
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Multi-omics Analysis Revealed the Diagnostic and Therapeutic Value of Immunogenic Cell Death-derived SCN5A in Hepatocellular Carcinoma.多组学分析揭示了免疫原性细胞死亡衍生的SCN5A在肝细胞癌中的诊断和治疗价值。
Mol Biotechnol. 2025 Apr 24. doi: 10.1007/s12033-025-01444-2.
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Effects of Metamizole, 4-Methylaminoantipyrine, and 4-Aminoantipyrine on LX-2 Liver Cell Line Viability and Apoptosis.安乃近、4-甲基氨基安替比林和4-氨基安替比林对LX-2肝细胞系活力和凋亡的影响。
Molecules. 2024 Dec 24;30(1):17. doi: 10.3390/molecules30010017.
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Neuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release.双氯芬酸和麦角胺对神经内分泌的调节：研究对神经元标志物和 GnRH 释放的影响。
Endocrine. 2024 Sep;85(3):1327-1336. doi: 10.1007/s12020-024-03822-3. Epub 2024 Apr 16.
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Genotoxic and cytotoxic effects of the drug dipyrone sodium in African green monkey kidney (Vero) cell line exposed in vitro.药物安乃近钠对体外培养的非洲绿猴肾（Vero）细胞系的遗传毒性和细胞毒性作用。
Naunyn Schmiedebergs Arch Pharmacol. 2021 Jul;394(7):1529-1535. doi: 10.1007/s00210-021-02078-2. Epub 2021 Mar 23.
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The Interplay of Dysregulated pH and Electrolyte Imbalance in Cancer.癌症中pH值失调与电解质失衡的相互作用
Cancers (Basel). 2020 Apr 7;12(4):898. doi: 10.3390/cancers12040898.
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Cell Size-Based Decision-Making of a Viral Gene Circuit.基于细胞大小的病毒基因回路决策。
Cell Rep. 2018 Dec 26;25(13):3844-3857.e5. doi: 10.1016/j.celrep.2018.12.009.
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Oxytetracycline have the therapeutic efficiency in CD133 HCC population through suppression CD133 expression by decreasing of protein stability of CD133.土霉素通过降低 CD133 蛋白稳定性抑制 CD133 表达，对 CD133 HCC 群体具有治疗效果。
Sci Rep. 2018 Oct 31;8(1):16100. doi: 10.1038/s41598-018-34301-1.
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Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1.安乃近、甲氧基安乃近和对乙酰氨基酚对胰腺癌细胞系PaTu 8988 t和Panc-1增殖、凋亡及坏死的影响。
BMC Pharmacol Toxicol. 2017 Dec 6;18(1):77. doi: 10.1186/s40360-017-0185-y.
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Cytotoxic effects of oxytetracycline residues in the bones of broiler chickens following therapeutic oral administration of a water formulation.口服水剂型药物治疗后，土霉素残留对肉鸡骨骼的细胞毒性作用。
Poult Sci. 2015 Aug;94(8):1979-85. doi: 10.3382/ps/pev141. Epub 2015 May 25.
本文引用的文献
1
The effects of high concentrations of vitamin C on cancer cells.高浓度维生素 C 对癌细胞的影响。
Nutrients. 2013 Sep 9;5(9):3496-505. doi: 10.3390/nu5093496.
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Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells.小檗碱对顺铂敏感和耐药人卵巢癌细胞叶酸代谢和多胺代谢相关酶表达的调节作用。
Int J Oncol. 2013 Oct;43(4):1269-80. doi: 10.3892/ijo.2013.2045. Epub 2013 Jul 31.
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Enhanced anti-tumor efficacy of aspirin combined with triptolide in cervical cancer cells.阿司匹林联合雷公藤甲素对宫颈癌细胞的抗肿瘤疗效增强
Asian Pac J Cancer Prev. 2013;14(5):3041-4. doi: 10.7314/apjcp.2013.14.5.3041.
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Novel chiral ferrocenylpyrazolo[1,5-a][1,4]diazepin-4-one derivatives--synthesis, characterization and inhibition against lung cancer cells.新型手性二茂铁基吡唑并[1,5-a][1,4]二氮杂*-4-酮衍生物的合成、表征及对肺癌细胞的抑制作用。
Eur J Med Chem. 2013 May;63:256-68. doi: 10.1016/j.ejmech.2013.02.016. Epub 2013 Feb 24.
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The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer.阿司匹林、姜黄素和萝卜硫素联合在胰腺癌化学预防中的作用机制。
Oncol Rep. 2013 Apr;29(4):1671-7. doi: 10.3892/or.2013.2276. Epub 2013 Feb 5.
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'Old drugs for new applications': can orthopedic research benefit from this strategy?“老药新用”：骨科研究能否从中受益？
Ther Adv Musculoskelet Dis. 2011 Aug;3(4):201-5. doi: 10.1177/1759720X11408487.
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Surf the post-translational modification network of p53 regulation.探索 p53 调控的翻译后修饰网络。
Int J Biol Sci. 2012;8(5):672-84. doi: 10.7150/ijbs.4283. Epub 2012 May 10.
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Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy.药物性抗坏血酸通过消耗 ATP 和诱导自噬诱导前列腺癌细胞毒性。
Anticancer Drugs. 2012 Apr;23(4):437-44. doi: 10.1097/CAD.0b013e32834fd01f.
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The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner.组蛋白去甲基酶 Jhdm1a/1b 以依赖维生素 C 的方式增强体细胞核重编程。
Cell Stem Cell. 2011 Dec 2;9(6):575-87. doi: 10.1016/j.stem.2011.10.005. Epub 2011 Nov 17.
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Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51.小檗碱通过下调同源重组修复蛋白 RAD51 增敏人食管癌细胞。
PLoS One. 2011;6(8):e23427. doi: 10.1371/journal.pone.0023427. Epub 2011 Aug 8.
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