Foote J W, Hinks L J
Ann Clin Biochem. 1987 Mar;24 ( Pt 2):198-202. doi: 10.1177/000456328702400214.
The total, albumin-bound, and alpha 2-macroglobulin-bound zinc concentrations in serum samples obtained from 20 haemodialysis patients have been measured. Blood leucocyte zinc contents were also determined. The total serum zinc concentrations in these samples were low, and in each case this was due to reduction in the zinc associated with albumin, although the concentrations of albumin itself were normal. There was no abnormality of the zinc bound to alpha 2-macroglobulin. These data demonstrate a disturbance of the plasma transport of zinc in haemodialysis patients which might be due either to a reduced affinity of albumin for zinc in uraemic subjects, or the result of zinc deficiency. The zinc contents of white blood cells were also significantly reduced, supporting the possibility that these patients were indeed zinc deficient.
已对20名血液透析患者的血清样本中的总锌、与白蛋白结合的锌以及与α2-巨球蛋白结合的锌浓度进行了测量。还测定了血液白细胞中的锌含量。这些样本中的血清总锌浓度较低，且在每种情况下这都是由于与白蛋白相关的锌减少所致，尽管白蛋白本身的浓度正常。与α2-巨球蛋白结合的锌没有异常。这些数据表明血液透析患者锌的血浆转运存在紊乱，这可能是由于尿毒症患者白蛋白对锌的亲和力降低，或者是锌缺乏的结果。白细胞中的锌含量也显著降低，支持了这些患者确实缺锌的可能性。
