Giroux E L, Durieux M, Schechter P J
Bioinorg Chem. 1976;5(3):211-8. doi: 10.1016/s0006-3061(00)82019-0.
The partition of zinc in human serum between two major zinc-binding proteins, albumin and alpha2-macroglobulin, was studied in 28 control subjects and in 156 hospitalized patients. Albumin-bound zinc was both the major and the more dynamic of the serum zinc components. Over a wide range of values the concentrations of albumin-bound zinc and total serum zinc were highly correlated (r=0.91) with each other, as were concentrations of albumin and albumin-bound zinc (r=0.69). alpha2-Macroglobulin-bound zinc was not strongly correlated either with total serum zinc or with the serum concentration of alpha2-macroglobulin. Twenty-four hour urinary excretion of zinc was not correlated with any of the serum zinc parameters. To a large extent it appears that total serum zinc concentration reflects serum albumin concentration.
在28名对照受试者和156名住院患者中，研究了锌在人血清中在两种主要锌结合蛋白——白蛋白和α2-巨球蛋白之间的分配情况。结合白蛋白的锌既是血清锌成分中的主要成分，也是更具动态变化的成分。在很宽的值范围内，结合白蛋白的锌浓度与总血清锌浓度高度相关（r = 0.91），白蛋白浓度与结合白蛋白的锌浓度也高度相关（r = 0.69）。结合α2-巨球蛋白的锌与总血清锌或α2-巨球蛋白的血清浓度均无强相关性。锌的24小时尿排泄量与任何血清锌参数均无相关性。在很大程度上，总血清锌浓度似乎反映了血清白蛋白浓度。
