失代偿期肝硬化患者血清锌在白蛋白和α2-巨球蛋白之间的分布情况。

Distribution of serum zinc between albumin and alpha2-macroglobulin in patients with decompensated hepatic cirrhosis.

作者信息

Schechter P J, Giroux E L, Schlienger J L, Hoenig V, Sjoerdsma A

出版信息

Eur J Clin Invest. 1976 Mar 31;6(2):147-50. doi: 10.1111/j.1365-2362.1976.tb00505.x.

DOI:10.1111/j.1365-2362.1976.tb00505.x

Abstract

Lower concentrations of total serum zinc (540 +/- 111 mug/1, mean +/- SEM), and of albumin-bound serum zinc (295 +/- 113 mug/1) and a higher concentration of alpha2-macroglobulin-bound zinc (245 +/- 69 mug/1) were found in 25 patients with decompensated hepatic cirrhosis, compared to 28 healthy subjects (835 +/- 91; 679 +/- 83; 156 +/- 27 mug/1 respectively). Levels of total and albumin-bound zinc were significantly and positively correlated with serum albumin levels. Higher levels of alpha2-macroglobulin-bound zinc were associated with higher levels of alpha2-macroglobulin in these patients (2.8 +/- 0.8 g/1) compared to normals (2.3 +/- 0.6). Hence, not only do decompensated cirrhotics exhibit a lower serum zinc level but a greater proportion of this zinc is associated with the tightly bound, and presumably metabolically more inert, serum fraction. This situation exaggerates the zinc deficiency state of the severe cirrhotic.

摘要

与28名健康受试者（分别为835±91、679±83、156±27μg/1）相比，25例失代偿期肝硬化患者血清总锌浓度（540±111μg/1，均值±标准误）、白蛋白结合锌浓度（295±113μg/1）较低，而α2-巨球蛋白结合锌浓度（245±69μg/1）较高。血清总锌和白蛋白结合锌水平与血清白蛋白水平呈显著正相关。与正常人（2.3±0.6g/1）相比，这些患者中α2-巨球蛋白结合锌水平较高与α2-巨球蛋白水平较高（2.8±0.8g/1）相关。因此，失代偿期肝硬化患者不仅血清锌水平较低，而且该锌的更大比例与紧密结合且可能代谢活性较低的血清成分相关。这种情况加剧了重度肝硬化患者的锌缺乏状态。