2. Nanomedicine and Biosensor Laboratory, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.
1. College of Engineering and Peking University Third Hospital, Peking University, Beijing 100871, China;
Theranostics. 2013 Dec 1;4(1):12-23. doi: 10.7150/thno.7275. eCollection 2013.
Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.
影像引导消融治疗已被应用于生物医学研究和临床试验中，是最有前途的癌症治疗方法之一。本文通过将全氟辛基溴化物（PFOB）和超顺磁性氧化铁纳米粒子（SPIOs）装载到聚乳酸（PLA）纳米胶囊（NCs）中，然后在表面形成聚乙二醇化金纳米壳，制备了多功能纳米胶囊。结果表明，这种多组分 NCs 可以作为纳米治疗剂，在人肿瘤异种移植模型中实现成功的双模式超声（US）/磁共振成像（MRI）引导光热消融，具有非侵入性。这种具有实时 US 和高分辨率 MR 成像功能的单一治疗剂，将为提供更全面的诊断信息和疾病进展动态提供巨大的价值，以准确确定靶向肿瘤组织中的治疗聚焦点位置，为对比成像引导光热治疗提供了巨大的潜力。
