Department of Chemistry, Jinan University, Guangzhou 510632, China.
Biomater Sci. 2018 Jan 30;6(2):372-387. doi: 10.1039/c7bm00894e.
Recently, two dimensional transition metal dichalcogenides (TMDCs) being used as nanomedicine have aroused great interest because of their unique photothermal properties. A simple liquid-phase method was used to prepare gadolinium (Gd)-doped molybdenum selenide (MoSe) nanosheets, and then using poly(ethylene glycol) (PEG) modification on the surface, MoSe(Gd)-PEG nanosheets were obtained which had high stability in physiological solutions and showed no obvious toxicity in vivo. It revealed that Gd used as a paramagnetic material for MoSe(Gd)-PEG provided a strong contrast effect in magnetic resonance imaging, furthermore, the MoSe showed strong absorption in the near infrared region, and therefore, MoSe(Gd)-PEG could be used as contrast agent for photoacoustic imaging (PAI). In in vitro experiments, it was found that MoSe(Gd)-PEG could effectively increase the temperature to help kill cancer cells under laser irradiation. In vivo experiments showed that there was an enhanced permeation and retention effect in the tumor after intravenous injection measured using magnetic resonance/photoacoustic (MR/PA) bimodal imaging. After photothermal therapy, a significant suppression effect was achieved for tumors in mice by injection of these nanosheets with laser irradiation. This work emphasized that the simple doped TMDC nanomaterials when combined with treatment and imaging functions achieve a cancer therapy, which will provide a good opportunity for future diagnosis and treatment of cancer.
最近，二维过渡金属二硫属化物（TMDCs）作为纳米医学材料引起了极大的兴趣，因为它们具有独特的光热特性。本文采用简单的液相法制备了钆（Gd）掺杂的二硒化钼（MoSe）纳米片，然后通过表面聚乙二醇（PEG）修饰，得到了在生理溶液中具有高稳定性且体内无明显毒性的 MoSe（Gd）-PEG 纳米片。研究结果表明，Gd 作为 MoSe（Gd）-PEG 的顺磁材料，在磁共振成像中提供了强烈的对比效果，此外，MoSe 在近红外区域具有很强的吸收，因此，MoSe（Gd）-PEG 可以用作光声成像（PAI）的造影剂。在体外实验中，发现 MoSe（Gd）-PEG 可以在激光照射下有效提高温度，有助于杀死癌细胞。体内实验表明，通过磁共振/光声（MR/PA）双模态成像测量，静脉注射后肿瘤内有增强的渗透和保留效应。光热治疗后，激光照射下注射这些纳米片可显著抑制小鼠肿瘤的生长。这项工作强调了简单掺杂 TMDC 纳米材料与治疗和成像功能相结合，实现了癌症治疗，为癌症的未来诊断和治疗提供了良好的机会。
