2型糖尿病患者血清F2-异前列腺素和氧化低密度脂蛋白水平与维生素D状态有关吗？一项病例对照研究。

Are Serum Levels of F2-Isoprostane and Oxidized-LDL Related to Vitamin D Status in Type 2 Diabetic Patients? A Case-Control Study.

作者信息

Javanbakht Mohammad Hassan, Mohammady Hamed, Fooladsaz Koorosh, Razzaghi Maryam, Zarei Mahnaz, Djalali Mahmoud

机构信息

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Department of Clinical Biochemistry, Zanjan University of Medical Sciences, Zanjan, Iran.

出版信息

Rep Biochem Mol Biol. 2016 Oct;5(1):26-32.

PMID:28070531

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5214680/

Abstract

BACKGROUND

Considerable evidence suggests that oxidative stress affects diabetes mellitus (DM) and contributes to its complications. Vitamin D has been shown to possess antioxidant properties. The aim of this study was to determine the association between serum levels of calcifediol (25-OH-D), an indicator of vitamin D status, and lipid profiles with oxidative stress in patients with type 2 diabetes mellitus (T2DM).

METHODS

In this case-control study, 57 T2DM patients with low vitamin D status (< 30 ng/mL) and 48 T2DM patients with normal vitamin D status (> 30 ng/mL) were enrolled. Fasting concentrations of 25-OH-D, calcium, phosphorus, parathyroid hormone (PTH), lipid profiles, fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), F2-isoprostane, and oxidized-low-density lipoprotein (ox-LDL) were measured.

RESULTS

The mean fasting serum concentrations of 25-OH-D, calcium, and phosphorus in patients with low vitamin D status were significantly lower than in controls (p < 0.001). The mean concentrations of ox-LDL, F2-isoprostane, total cholesterol, and LDL were significantly higher in patients with low vitamin D status than in controls. There was a negative correlation between vitamin D levels and F2-isoprostane (r = 0.647and P = 0.0001), LDL (r = -0.218 and P = 0.030), and ox-LDL (r = -0.637 and P = 0.0001).

CONCLUSION

The results of present study indicated that serum concentrations of 25-OH-D were inversely correlated with F2-isoprostane, LDL, and ox-LDL. Therefore, vitamin D may have a beneficial effect on the control of lipid profiles and oxidative stress in T2DM patients.

摘要

背景

大量证据表明氧化应激会影响糖尿病（DM）并导致其并发症。维生素D已被证明具有抗氧化特性。本研究的目的是确定2型糖尿病（T2DM）患者中维生素D状态指标骨化二醇（25-OH-D）的血清水平与脂质谱和氧化应激之间的关联。

方法

在这项病例对照研究中，纳入了57名维生素D水平低（<30 ng/mL）的T2DM患者和48名维生素D水平正常（>30 ng/mL）的T2DM患者。测量了25-OH-D、钙、磷、甲状旁腺激素（PTH）、脂质谱、空腹血糖（FBS）、糖化血红蛋白（HbA1c）、F2-异前列腺素和氧化低密度脂蛋白（ox-LDL）的空腹浓度。

结果

维生素D水平低的患者的空腹血清25-OH-D、钙和磷的平均浓度显著低于对照组（p<0.001）。维生素D水平低的患者的ox-LDL、F2-异前列腺素、总胆固醇和低密度脂蛋白（LDL）的平均浓度显著高于对照组。维生素D水平与F2-异前列腺素（r = 0.647，P = 0.0001）、LDL（r = -0.218，P = 0.030）和ox-LDL（r = -0.637，P = 0.0001）之间存在负相关。