Hubei Key Laboratory of TCM Based Functional Food Quality and Safety, Jing Brand Company, Daye 435100, Hubei, China.
Molecules. 2014 Jan 6;19(1):568-80. doi: 10.3390/molecules19010568.
Glyceollin I, an induced phytoalexin isolated from soybean, has been reported to have various bioactivities, including anti-bacterial, anti-nematode, anti-fungal, anti-estrogenic and anti-cancer, anti-oxidant, anti-inflammatory, insulin sensitivity enhancing, and attenuation of vascular contractions. Here we show that glyceollin I has hormesis and extends yeast life span at low (nM) doses in a calorie restriction (CR)-dependent manner, while it reduces life span and inhibits yeast cell proliferation at higher (μM) doses. In contrast, the other two isomers (glyceollin II and III) cannot extend yeast life span and only show life span reduction and antiproliferation at higher doses. Our results in anti-aging activity indicate that glyceollin I might be a promising calorie restriction mimetic candidate, and the high content of glyceollins could improve the bioactivity of soybean as functional food ingredients.
大豆诱导植保素之一的黄豆苷元 I 具有多种生物活性，包括抗细菌、抗线虫、抗真菌、抗雌激素和抗癌、抗氧化、抗炎、增强胰岛素敏感性以及减轻血管收缩等作用。在这里，我们发现黄豆苷元 I 在低剂量（nM）时具有兴奋效应，并依赖于热量限制（CR）延长酵母的寿命，而在高剂量（μM）时则降低寿命并抑制酵母细胞增殖。相比之下，另外两种同分异构体（黄豆苷元 II 和 III）不能延长酵母的寿命，而只是在高剂量时表现出寿命缩短和抑制细胞增殖的作用。我们在抗衰老活性方面的研究结果表明，黄豆苷元 I 可能是一种很有前途的热量限制模拟候选物，而黄豆苷元的高含量可以提高大豆作为功能性食品成分的生物活性。
