HeartMate II心室辅助装置中的血栓形成模式：临床观察结果可通过数值模拟预测。
Thrombus formation patterns in the HeartMate II ventricular assist device: clinical observations can be predicted by numerical simulations.
作者信息
Chiu Wei-Che, Slepian Marvin J, Bluestein Danny
机构信息
From the *Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York; and †Sarver Heart Center, University of Arizona, Tucson, Arizona.
出版信息
ASAIO J. 2014 Mar-Apr;60(2):237-40. doi: 10.1097/MAT.0000000000000034.
Abstract
Postimplant device thrombosis remains a life-threatening complication and limitation of continuous-flow ventricular assist devices (VADs). Using advanced computational fluid dynamic (CFD) simulations, we successfully depicted various flow patterns, recirculation zones, and stagnant platelet trajectories which promote thrombus formation and observed that they matched actual thrombus formation patterns observed in Thoratec HeartMate II VADs explanted from patients with pump thrombosis. Previously, these small eddies could not be captured by either digital particle image velocimetry or CFD due to insufficient resolution. Our study successfully demonstrated the potential capability of advanced CFD to be adopted for device optimization, leading to enhanced safety and efficacy of VADs for long-term destination therapy.
摘要
植入后装置血栓形成仍然是连续流心室辅助装置（VAD）的一种危及生命的并发症和局限性。通过先进的计算流体动力学（CFD）模拟，我们成功描绘了促进血栓形成的各种流动模式、再循环区域和停滞的血小板轨迹，并观察到它们与从患有泵血栓形成的患者身上取出的Thoratec HeartMate II VAD中观察到的实际血栓形成模式相匹配。以前，由于分辨率不足，这些小漩涡无法通过数字粒子图像测速法或CFD捕获。我们的研究成功证明了先进CFD用于装置优化的潜在能力，从而提高了VAD用于长期目标治疗的安全性和有效性。
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