miR-146a rs2910164和miR-499 rs3746444基因多态性与肺结核易感性之间无关联。
Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis.
作者信息
Naderi Mohammad, Hashemi Mohammad, Khorgami Parisa, Koshki Maliheh, Ebrahimi Mahboubeh, Amininia Shadi, Sharifi-Mood Batool, Taheri Mohsen
机构信息
Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Int J Mol Cell Med. 2015 Winter;4(1):40-5.
Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings.
微小RNA（miRNA）中的单核苷酸多态性（SNP）可能会改变其表达水平或加工过程，并导致对多种疾病的易感性增加。我们的研究旨在评估伊朗人群样本中miRNA - 146a rs2910164和miRNA - 499 rs3746444多态性与肺结核（PTB）易感性之间的可能关联。这项病例对照研究对202例PTB患者和204名健康个体进行。使用四重扩增难治突变系统 - 聚合酶链反应（T - ARMS - PCR）进行基因分型。结果表明，在伊朗人群样本中，miRNA - 499 rs3746444和miRNA - 146a rs2910164均与PTB风险无关。需要开展涉及不同种族的更大规模研究来验证我们的发现。
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