Molecular Link between Liver Fibrosis and Hepatocellular Carcinoma.
作者信息
Sakurai Toshiharu, Kudo Masatoshi
机构信息
Department of Gastroenterology and Hepatology, Kinki University, Osaka, Japan.
出版信息
Liver Cancer. 2013 Aug;2(3-4):365-6. doi: 10.1159/000343851.
Abstract
摘要
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本文引用的文献
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From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence.从肝硬化到肝细胞癌：关于炎症和细胞衰老的新分子见解
Liver Cancer. 2013 Aug;2(3-4):367-83. doi: 10.1159/000343852.
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A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence.一种涉及 p38、Tip60 和 PRAK 的翻译后修饰级联反应介导了癌基因诱导的衰老。
Mol Cell. 2013 Jun 6;50(5):699-710. doi: 10.1016/j.molcel.2013.04.013. Epub 2013 May 16.
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p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species.p38α 通过抑制活性氧的积累来抑制肝纤维化和随后的肝癌发生。
Cancer Res. 2013 Jan 1;73(1):215-24. doi: 10.1158/0008-5472.CAN-12-1602. Epub 2012 Dec 27.
4
Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma.JNK 的激活和 CD133 的高表达水平预示着肝癌对索拉非尼的反应较差。
Br J Cancer. 2012 Jun 5;106(12):1997-2003. doi: 10.1038/bjc.2012.145. Epub 2012 May 17.
5
p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells.p38MAPK 和 JNK 拮抗作用控制阿霉素处理的内皮祖细胞衰老和细胞质 p16INK4A 的表达。
PLoS One. 2010 Dec 20;5(12):e15583. doi: 10.1371/journal.pone.0015583.
6
Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation.肝细胞 IKKβ/NF-κB 通过阻止氧化应激驱动的 STAT3 激活来抑制肿瘤促进和进展。
Cancer Cell. 2010 Mar 16;17(3):286-97. doi: 10.1016/j.ccr.2009.12.048.
7
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.氧化应激诱导的肝细胞坏死和白细胞介素-1α释放介导致癌物诱导的代偿性增殖和肝脏肿瘤发生。
Cancer Cell. 2008 Aug 12;14(2):156-65. doi: 10.1016/j.ccr.2008.06.016.
8
Suppression of p53-dependent senescence by the JNK signal transduction pathway.JNK信号转导通路对p53依赖的衰老的抑制作用。
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15759-64. doi: 10.1073/pnas.0707782104. Epub 2007 Sep 24.
9
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.由于依赖MyD88的白细胞介素-6产生存在性别差异，导致肝癌中的性别差异。
Science. 2007 Jul 6;317(5834):121-4. doi: 10.1126/science.1140485.
10
Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation.肝脏核因子-κB活性丧失通过持续激活c-Jun氨基末端激酶1增强化学性肝癌发生。
Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10544-51. doi: 10.1073/pnas.0603499103. Epub 2006 Jun 28.
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