Department of Cardiology, Tel Aviv Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Cardiology, Tel Aviv Medical Center, Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Atherosclerosis. 2014 Jan;232(1):149-54. doi: 10.1016/j.atherosclerosis.2013.10.033. Epub 2013 Nov 12.
The "Slow Coronary Flow" (SCF) phenomenon in the presence of angiographically normal coronaries is attributed to microvascular and endothelial dysfunction. The microcirculation can be non-invasively assessed by measuring retinal blood flow velocity. The aim of the present study was to evaluate the efficacy of the "Retinal Functional Imager" (RFI) device as a noninvasive method of diagnosing patients with slow coronary flow.
Coronary blood flow velocity assessed by corrected TIMI Frame Count and retinal arterioles blood flow assessed by RFI were measured in 28 consecutive patients with normal coronary arteries. The patients were divided into 2 groups: a slow coronary flow (SCF) and a normal coronary flow (NCF) groups.
Inverse correlation was found between retinal and coronary blood flows so that higher retinal arterial flow velocity was observed in the SCF group (3.8 ± 1.1 mm/s vs. 2.9 ± 0.61 mm/s, respectively, p = 0.022). RFI provided 73% sensitivity and 77% specificity for diagnosing SCF using ROC analysis. Additionally, patients with SCF had higher values of serum LDL cholesterol (104.7 ± 18.93 mg/dl vs. 81.55 ± 14.62 mg/dl in NCF, p = 0.005), Glucose (96.9 ± 23.0 mg/dl vs. 83.55 ± 9.7 mg/dl in NCF, p = 0.024), and lower percentage of statin consumption (40.0% vs. 76.9% in NCF, p = 0.049).
Slow coronary blood flow can be non-invasively diagnosed with Retinal Functional Imager. Patients with normal coronary arteries and slow coronary blood flow have high retinal arteriolar blood flow. Early non-invasive diagnosis of SCF might help detect individuals who are at higher risk to develop coronary atherosclerosis, and to provide them with early preventive measures.
在冠状动脉造影正常的情况下，“慢血流”（SCF）现象归因于微血管和内皮功能障碍。视网膜血流速度的测量可以无创地评估微循环。本研究的目的是评估“视网膜功能成像仪”（RFI）作为一种无创方法诊断慢血流患者的疗效。
在 28 例冠状动脉正常的连续患者中，测量校正 TIMI 帧数评估的冠状动脉血流速度和 RFI 评估的视网膜小动脉血流速度。患者分为两组：慢血流（SCF）组和正常冠状动脉血流（NCF）组。
发现视网膜和冠状动脉血流之间存在负相关，因此在 SCF 组观察到较高的视网膜动脉血流速度（3.8 ± 1.1 mm/s 与 2.9 ± 0.61 mm/s，分别，p = 0.022）。ROC 分析显示，RFI 对 SCF 的诊断具有 73%的敏感性和 77%的特异性。此外，SCF 患者的血清 LDL 胆固醇值较高（104.7 ± 18.93 mg/dl 与 NCF 中的 81.55 ± 14.62 mg/dl，p = 0.005），血糖值较高（96.9 ± 23.0 mg/dl 与 NCF 中的 83.55 ± 9.7 mg/dl，p = 0.024），他汀类药物使用率较低（40.0%与 NCF 中的 76.9%，p = 0.049）。
视网膜功能成像仪可无创诊断慢血流。正常冠状动脉和慢血流的患者有较高的视网膜小动脉血流。早期非侵入性诊断 SCF 可能有助于发现发生冠状动脉粥样硬化风险较高的个体，并为他们提供早期预防措施。
